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脂肪干细胞是具有两性差异的细胞，具有前脂肪细胞和固有成纤维细胞的双重作用。

Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts.

机构信息

Department of Medicine, Huddinge, Karolinska Institutet Campus Flemingsberg, Neo building, 141 52, Huddinge, Sweden.

Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

出版信息

Nat Commun. 2024 Sep 2;15(1):7643. doi: 10.1038/s41467-024-51867-9.

DOI:10.1038/s41467-024-51867-9
PMID:39223126
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11369120/
Abstract

Cell identities are defined by intrinsic transcriptional networks and spatio-temporal environmental factors. Here, we explored multiple factors that contribute to the identity of adipose stem cells, including anatomic location, microvascular neighborhood, and sex. Our data suggest that adipose stem cells serve a dual role as adipocyte precursors and fibroblast-like cells that shape the adipose tissue's extracellular matrix in an organotypic manner. We further find that adipose stem cells display sexual dimorphism regarding genes involved in estrogen signaling, homeobox transcription factor expression and the renin-angiotensin-aldosterone system. These differences could be attributed to sex hormone effects, developmental origin, or both. Finally, our data demonstrate that adipose stem cells are distinct from mural cells, and that the state of commitment to adipogenic differentiation is linked to their anatomic position in the microvascular niche. Our work supports the importance of sex and microvascular function in adipose tissue physiology.

摘要

细胞的身份由内在的转录网络和时空环境因素决定。在这里，我们探讨了多种因素对脂肪干细胞身份的影响，包括解剖位置、微血管环境和性别。我们的数据表明，脂肪干细胞作为脂肪细胞前体和成纤维样细胞发挥双重作用，以器官样方式塑造脂肪组织的细胞外基质。我们进一步发现，脂肪干细胞在涉及雌激素信号、同源盒转录因子表达和肾素-血管紧张素-醛固酮系统的基因方面存在性别二态性。这些差异可能归因于性激素的影响、发育起源或两者兼有。最后，我们的数据表明，脂肪干细胞与壁细胞不同，并且向脂肪生成分化的状态与其在微血管龛中的解剖位置有关。我们的工作支持了性别和微血管功能在脂肪组织生理学中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/18fc8d5190e9/41467_2024_51867_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/00578671a648/41467_2024_51867_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/713d55f06af1/41467_2024_51867_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/035ef68a75ba/41467_2024_51867_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/45b08a9c1d8d/41467_2024_51867_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/3bf92bde111c/41467_2024_51867_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/18fc8d5190e9/41467_2024_51867_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/00578671a648/41467_2024_51867_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/713d55f06af1/41467_2024_51867_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/035ef68a75ba/41467_2024_51867_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/45b08a9c1d8d/41467_2024_51867_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/3bf92bde111c/41467_2024_51867_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7477/11369120/18fc8d5190e9/41467_2024_51867_Fig6_HTML.jpg

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