Al-Dahimavi Sareh, Safaralizadeh Reza, Khalaj-Kondori Mohammad
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Biochem Genet. 2024 Sep 2. doi: 10.1007/s10528-024-10909-z.
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disorder affecting white and gray matter. This study aimed to investigate the association between clinical outcomes in MS patients and the levels of certain molecules in their serum, including ACTH, IL-17, and specific miRNAs: miR-26a, miR-34a, miR-155-5p, and miR-146a. Fifty healthy people and 75 blood samples from MS patients were selected. MS patients had higher expression levels of IL-17, miR-26a, miR-34a, and miR-146a compared to healthy individuals (p < 0.0001). There was no significant difference in miR-155-5p expression between the two groups (p = 0.203). MS patients also had higher serum levels of ACTH compared to the normal population (p < 0.0001). In MS patients, there was a negative correlation between IL-17 and miR-155-5p expression levels (p = 0.048, r = - 0.229). Similarly, a significant negative correlation was observed between ACTH and miR-155-5p in the control group (p = 0.044, r = - 0.286). The study's analysis revealed no significant difference in the expression of miR-155-5p between MS patients and normal individuals; the study's examination revealed that the expression level of IL-17, miR-26a, miR-34a, and miR-146a was higher in MS patients than in normal individuals.
多发性硬化症（MS）是一种影响白质和灰质的炎症性神经退行性疾病。本研究旨在调查MS患者的临床结局与其血清中某些分子水平之间的关联，这些分子包括促肾上腺皮质激素（ACTH）、白细胞介素-17（IL-17）以及特定的微小RNA（miRNA）：miR-26a、miR-34a、miR-155-5p和miR-146a。选取了50名健康人和75份来自MS患者的血液样本。与健康个体相比，MS患者的IL-17、miR-26a、miR-34a和miR-146a表达水平更高（p < 0.0001）。两组之间miR-155-5p表达无显著差异（p = 0.203）。与正常人群相比，MS患者的血清ACTH水平也更高（p < 0.0001）。在MS患者中，IL-17与miR-155-5p表达水平呈负相关（p = 0.048，r = -0.229）。同样，在对照组中ACTH与miR-155-5p之间也观察到显著的负相关（p = 0.044，r = -0.286）。该研究分析显示，MS患者与正常个体之间miR-155-5p表达无显著差异；该研究检测显示，MS患者中IL-17、miR-26a、miR-34a和miR-146a的表达水平高于正常个体。
