Jiang Ligang, Liu Mengting, Yu Meiting, Lu Wei, Zhang Zhe, Tong Yuhua
Quzhou Aliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China.
The Second Xiang Ya Hospital, Central South University, Changsha, Hunan, China.
Front Cell Dev Biol. 2024 Aug 19;12:1467374. doi: 10.3389/fcell.2024.1467374. eCollection 2024.
To investigate the correlation between retinal vascular changes and ICA stenosis by measuring retinal vessels using full-width-at-half-maximum (FWHM) and intelligent image recognition.
This research selected patients who were admitted to the Vascular Surgery Department of Quzhou People's Hospital from January 2018 to December 2020 and were preparing for Carotid Artery Stenting (CAS). Participants were divided into two groups: without ICA stenosis (Group 0) and with ICA stenosis (Group 1). A total of 109 cases were included in the study, with 50 cases in Group 1 and 59 cases in Group 0. Vascular images of superior temporal zone B of the retina were obtained by spectral domain optical coherence tomography (SD-OCT). The edges of retinal vessels were identified by FWHM. Each vessel of all subjects was measured three times with the FWHM, and the average value was taken to obtain the retinal arteriolar lumen diameter (RALD), retinal arteriolar outer diameter (RAOD), retinal venular lumen diameter (RVLD), and retinal venular outer diameter (RVOD),Arterial Wall Thickness (AWT),Venular Wall Thickness (VWT)=(RVOD-RVLD)/2,Arteriovenous Ratio (AVR) = RAOD/RVOD.
We found that compared to Group 0, Group 1 had smaller RALD ( < 0.001) and RAOD ( < 0.001), and wider RVOD ( < 0.001), with thicker VWT ( < 0.001). When compared with the contralateral eye in Group 1, the ipsilateral eye exhibited even smaller RALD,RAOD and AVR ( < 0.001, < 0.001, < 0.001). After CAS, the RALD,RAOD and AVR in Group 1 increased ( < 0.001, < 0.001, < 0.001),while the RVLD and RVOD decreased ( < 0.05, < 0.001). Our research reveals a significant correlation between retinal vascular changes and internal ICA stenosis.
Utilizing SD-OCT in conjunction with the FWHM,we achieved a non-invasive, intelligent, stable, and precise acquisition of data pertaining to retinal vessels. These findings underscore a significant correlation between alterations in retinal vascular structure and the presence of ICA stenosis, as demonstrated by our research.
通过使用半高全宽（FWHM）和智能图像识别测量视网膜血管，研究视网膜血管变化与颈内动脉（ICA）狭窄之间的相关性。
本研究选取2018年1月至2020年12月在衢州市人民医院血管外科住院并准备进行颈动脉支架置入术（CAS）的患者。参与者分为两组：无ICA狭窄组（0组）和有ICA狭窄组（1组）。本研究共纳入109例患者，其中1组50例，0组59例。通过光谱域光学相干断层扫描（SD-OCT）获取视网膜颞上B区的血管图像。通过FWHM识别视网膜血管边缘。对所有受试者的每条血管用FWHM测量3次，取平均值得到视网膜小动脉管腔直径（RALD）、视网膜小动脉外径（RAOD）、视网膜小静脉管腔直径（RVLD）、视网膜小静脉外径（RVOD）、动脉壁厚度（AWT）、静脉壁厚度（VWT）=（RVOD - RVLD）/2、动静脉比（AVR）= RAOD/RVOD。
我们发现，与0组相比，1组的RALD（<0.001）和RAOD（<0.001）较小，RVOD较宽（<0.001），VWT较厚（<0.001）。与1组的对侧眼相比，同侧眼的RALD、RAOD和AVR更小（<0.001，<0.001，<0.001）。CAS术后，1组的RALD、RAOD和AVR增加（<0.001，<0.001，<0.001），而RVLD和RVOD减小（<0.05，<0.001）。我们的研究揭示了视网膜血管变化与颈内动脉内部狭窄之间存在显著相关性。
利用SD-OCT结合FWHM，我们实现了对视网膜血管数据的无创、智能、稳定且精确的采集。我们的研究表明，这些发现强调了视网膜血管结构改变与ICA狭窄的存在之间存在显著相关性。
