Tripathee Sabin, Benyovszky Alexander, Devbhandari Ruchi, Quiza Katherine, Boris James
Internal Medicine, Jefferson Einstein Montgomery Hospital, East Norriton, USA.
Cureus. 2024 Aug 2;16(8):e66039. doi: 10.7759/cureus.66039. eCollection 2024 Aug.
Minoxidil is a potent directly acting vasodilator previously used in treatment-resistant hypertension. It possesses several serious side effects including fluid retention, worsening of heart failure, reflex tachycardia, angina, myocardial infarction, pericardial effusion, and hypotension. It is currently reserved for treating alopecia and readily available over the counter as a topical formulation. Intentional/accidental ingestion of topical minoxidil can cause refractory circulatory shock requiring aggressive hydration and vasopressor support. We present a case of a young female with unintentional ingestion of minoxidil leading to severe circulatory shock and acute pulmonary edema. Minoxidil, a common hair loss treatment, is highly dangerous if ingested. Immediate identification and treatment are crucial, involving fluid resuscitation and vasopressors for severe circulatory shock. Midodrine, an alpha-adrenergic agonist, can reduce ICU stay by shortening IV vasopressor usage.
米诺地尔是一种强效的直接作用血管扩张剂，曾用于治疗顽固性高血压。它有多种严重副作用，包括液体潴留、心力衰竭恶化、反射性心动过速、心绞痛、心肌梗死、心包积液和低血压。目前它仅用于治疗脱发，有非处方的局部用制剂可供使用。故意/意外摄入局部用米诺地尔可导致难治性循环性休克，需要积极补液和使用血管加压药支持治疗。我们报告一例年轻女性意外摄入米诺地尔导致严重循环性休克和急性肺水肿的病例。米诺地尔是一种常见的脱发治疗药物，摄入后非常危险。立即识别和治疗至关重要，对于严重循环性休克需进行液体复苏和使用血管加压药。去氧肾上腺素，一种α-肾上腺素能激动剂，可通过缩短静脉血管加压药使用时间来减少重症监护病房住院时间。
