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本文引用的文献

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Novel therapeutics to treat chronic pancreatitis: targeting pancreatic stellate cells and macrophages.治疗慢性胰腺炎的新疗法：靶向胰腺星状细胞和巨噬细胞。
Expert Rev Gastroenterol Hepatol. 2024 Apr-May;18(4-5):171-183. doi: 10.1080/17474124.2024.2355969. Epub 2024 May 18.
2
Cholesterol metabolism in tumor microenvironment: cancer hallmarks and therapeutic opportunities.肿瘤微环境中的胆固醇代谢：癌症特征与治疗机遇
Int J Biol Sci. 2024 Mar 17;20(6):2044-2071. doi: 10.7150/ijbs.92274. eCollection 2024.
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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy.肿瘤微环境重塑与癌症免疫治疗中的纳米颗粒。
J Hematol Oncol. 2024 Apr 2;17(1):16. doi: 10.1186/s13045-024-01535-8.
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Fundamental insights and molecular interactions in pancreatic cancer: Pathways to therapeutic approaches.胰腺癌的基础见解和分子相互作用：治疗方法的途径。
Cancer Lett. 2024 Apr 28;588:216738. doi: 10.1016/j.canlet.2024.216738. Epub 2024 Feb 23.
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Antitumor effect of tubeimoside-I on murine colorectal cancers through PKM2-dependent pyroptosis and immunomodulation.土贝母苷甲通过依赖PKM2的细胞焦亡和免疫调节对小鼠结直肠癌的抗肿瘤作用
Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun;397(6):4069-4087. doi: 10.1007/s00210-023-02855-1. Epub 2023 Nov 27.
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Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells.肿瘤进展中的微环境调控：癌相关成纤维细胞与免疫细胞间的相互作用。
Biomed Pharmacother. 2023 Nov;167:115622. doi: 10.1016/j.biopha.2023.115622. Epub 2023 Sep 30.
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Pancreatic ductal adenocarcinoma chemoresistance: From metabolism reprogramming to novel treatment.胰腺导管腺癌的化疗耐药性：从代谢重编程到新疗法
Chin Med J (Engl). 2024 Feb 20;137(4):408-420. doi: 10.1097/CM9.0000000000002758. Epub 2023 Aug 4.
8
Fasting blood glucose and risk of incident pancreatic cancer.空腹血糖与新发胰腺癌风险。
PLoS One. 2022 Oct 27;17(10):e0274195. doi: 10.1371/journal.pone.0274195. eCollection 2022.
9
Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes.基于人参皂苷 Rg3 的脂质体靶向治疗三阴性乳腺癌及重塑肿瘤微环境。
J Nanobiotechnology. 2022 Sep 15;20(1):414. doi: 10.1186/s12951-022-01623-2.
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Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs.通过胆固醇与 CRAC 基序的直接结合来调节 PD-L1。
Sci Adv. 2022 Aug 26;8(34):eabq4722. doi: 10.1126/sciadv.abq4722.

新型雷公藤红素脂质体药物递送系统联合吉西他滨治疗胰腺癌。

Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer.

机构信息

School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300000, China.

出版信息

Nanomedicine (Lond). 2024;19(24):1977-1993. doi: 10.1080/17435889.2024.2382076. Epub 2024 Sep 3.

DOI:10.1080/17435889.2024.2382076
PMID:39225145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11485868/
Abstract

To evaluate the anti-pancreatic cancer effect of novel Tubeimoside I multifunctional liposomes combined with gemcitabine. Liposomes were prepared through the thin film hydration method, with evaluations conducted on parameters including encapsulation efficiency (EE%), particle size, polydispersity index (PDI), zeta potential (ZP), storage stability, and release over a 7-day period. The cellular uptake rate, therapeutic efficacy and and the role of immune microenvironment modulation were evaluated. The novel Tubeimoside I multifunctional liposomal exhibited good stability, significant anti-cancer activity, and immune microenvironment remodeling effects. Furthermore, it showed a safety profile. This study underscores the potential of Novel Tubeimoside I multifunctional liposomal as a promising treatment option for pancreatic cancer.

摘要

评价新型雷公藤红素多功能脂质体与吉西他滨联合治疗胰腺癌的效果。采用薄膜水化法制备脂质体，评价其包封率（EE%）、粒径、多分散指数（PDI）、Zeta 电位（ZP）、储存稳定性和 7 天内的释放情况。评估细胞摄取率、治疗效果和免疫微环境调节作用。新型雷公藤红素多功能脂质体具有良好的稳定性、显著的抗癌活性和免疫微环境重塑作用，且安全性良好。本研究强调了新型雷公藤红素多功能脂质体作为胰腺癌治疗的一种有前途的选择。