Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Hum Brain Mapp. 2024 Sep;45(13):e70015. doi: 10.1002/hbm.70015.
Decreasing body mass index (BMI) reduces head motion in resting-state fMRI (rs-fMRI) data. Yet, the mechanism by which BMI affects head motion remains poorly understood. Understanding how BMI interacts with respiration to affect head motion can improve head motion reduction strategies. A total of 254 patients with back pain were included in this study, each of whom had two visits (interval time = 13.85 ± 7.81 weeks) during which two consecutive re-fMRI scans were obtained. We investigated the relationships between head motion and demographic and pain-related characteristics-head motion was reliable across scans and correlated with age, pain intensity, and BMI. Multiple linear regression models determined that BMI was the main determinant in predicting head motion. BMI was also associated with two features derived from respiration signal. Anterior-posterior and superior-inferior motion dominated both overall motion magnitude and the coupling between motion and respiration. BMI interacted with respiration to influence motion only in the pitch dimension. These findings indicate that BMI should be a critical parameter in both study designs and analyses of fMRI data.
体重指数（BMI）的降低可减少静息态 fMRI（rs-fMRI）数据中的头部运动。然而，BMI 影响头部运动的机制仍知之甚少。了解 BMI 如何与呼吸相互作用影响头部运动，可以改进头部运动减少策略。本研究共纳入 254 例腰痛患者，每位患者均有两次就诊（间隔时间=13.85±7.81 周），两次就诊期间连续进行两次重复 fMRI 扫描。我们研究了头部运动与人口统计学和疼痛相关特征之间的关系——头部运动在两次扫描中具有可重复性，并与年龄、疼痛强度和 BMI 相关。多元线性回归模型确定 BMI 是预测头部运动的主要决定因素。BMI 还与呼吸信号的两个特征相关。前后和上下运动主导了整体运动幅度以及运动与呼吸之间的耦合。BMI 仅在俯仰维度与呼吸相互作用影响运动。这些发现表明，BMI 应成为 fMRI 数据研究设计和分析中的关键参数。
