Department of Pharmacy, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu 210008, China.
Nano Lett. 2024 Sep 18;24(37):11697-11705. doi: 10.1021/acs.nanolett.4c03314. Epub 2024 Sep 3.
Osteoarthritis (OA) is a degenerative joint disease characterized by obscure etiology and unsatisfactory therapeutic outcomes, making the development of new efficient therapies urgent. Superfluous reactive oxygen species (ROS) have historically been considered one of the crucial factors inducing the pathological progression of OA. Ultrasmall Prussian blue nanoparticles (USPBNPs), approximately sub-5 nm in size, are developed by regulating the configuration of polyvinylpyrrolidone chains. USPBNPs display an excellent ROS eliminating capacity and catalase-like activity, capable of decomposing hydrogen peroxide (HO) into O. The anti-inflammatory mechanism of USPBNPs can be attributed to repolarizing macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotype by decreasing the ROS levels accompanied by O improvement. Additionally, USPBNPs exhibit an exciting therapeutic efficiency against OA, comparable to that of hydrocortisone in vivo. This study not only develops a new therapeutic agent for OA but also offers an estimable insight into the application of the nanozyme.
骨关节炎（OA）是一种退行性关节疾病，其病因不明，治疗效果不理想，因此迫切需要开发新的有效治疗方法。过多的活性氧（ROS）一直被认为是诱导 OA 病理进展的关键因素之一。超小普鲁士蓝纳米颗粒（USPBNPs）通过调节聚乙烯吡咯烷酮链的构象而被开发出来，其尺寸约为 5nm 以下。USPBNPs 具有出色的 ROS 清除能力和类过氧化物酶活性，能够将过氧化氢（HO）分解为 O。USPBNPs 的抗炎机制可以归因于通过降低 ROS 水平并伴随着 O 的改善，将巨噬细胞从促炎 M1 表型重极化为抗炎 M2 表型。此外，USPBNPs 对 OA 具有令人兴奋的治疗效果，与体内的氢化可的松相当。这项研究不仅为 OA 开发了一种新的治疗剂，而且还为纳米酶的应用提供了宝贵的见解。
