Kwon Hee-Young, Jung Yuna, Jeon Hojeong, Han Hyung-Seop
Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Bioact Mater. 2025 Feb 13;48:71-99. doi: 10.1016/j.bioactmat.2025.01.023. eCollection 2025 Jun.
Prussian blue (PB) has garnered considerable scholarly interest in the field of biomedical research owing to its notably high biocompatibility, formidable multi-enzyme mimetic capabilities, and established clinical safety profile. These properties in combination with its reactive oxygen species (ROS) scavenging activity have facilitated significant progress in disease diagnosis and therapy for various ROS-mediated pathologies, where overproduced ROS exacerbates disease symptoms. Additionally, the underlying ROS-associated mechanisms are disease-specific. Hence, we systematically examined the role of ROS and its basic underlying mechanisms in representative disease categories and comprehensively reviewed the effect of PB-based materials in effectively alleviating pathological states. Furthermore, we present a thorough synthesis of disease-specific design methodologies and prospective directions for PB as a potent ROS-scavenging biotherapeutic material with emphasis on its applications in neurological, cardiovascular, inflammatory, and other pathological states. Through this review, we aim to accelerate the progress of research on disease treatment using PB-based integrated therapeutic system.
普鲁士蓝（PB）因其显著的高生物相容性、强大的多酶模拟能力以及已确立的临床安全性，在生物医学研究领域引起了相当大的学术关注。这些特性与其活性氧（ROS）清除活性相结合，推动了针对各种ROS介导的病理学疾病诊断和治疗的重大进展，在这些疾病中，过量产生的ROS会加剧疾病症状。此外，潜在的ROS相关机制因疾病而异。因此，我们系统地研究了ROS在代表性疾病类别中的作用及其基本潜在机制，并全面综述了基于PB的材料在有效缓解病理状态方面的作用。此外，我们全面综合了针对特定疾病的设计方法以及PB作为一种有效的ROS清除生物治疗材料的未来发展方向，重点介绍了其在神经、心血管、炎症和其他病理状态中的应用。通过这篇综述，我们旨在加速基于PB的综合治疗系统在疾病治疗研究方面的进展。
