College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing 210023, China.
Department of Biochemistry and Molecular Biology, School of Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese Medicine, Nanjing 210023, China.
J Mater Chem B. 2024 Oct 9;12(39):9795-9820. doi: 10.1039/d4tb00741g.
Cancer remains the leading cause of human death worldwide. Compared to traditional therapies, tumor immunotherapy has received a lot of attention and research focus due to its potential to activate both innate and adaptive immunity, low toxicity to normal tissue, and long-term immune activity. However, its clinical effectiveness and large-scale application are limited due to the immunosuppression microenvironment, lack of spatiotemporal control, expensive cost, and long manufacturing time. Recently, nanomaterial combined engineered bacteria have emerged as a promising solution to the challenges of tumor immunotherapy, which offers spatiotemporal control, reversal of immunosuppression, and scalable production. Therefore, we summarize the latest research on nanomaterial-assisted engineered bacteria for precise tumor immunotherapies, including the cross-talk of nanomaterials and bacteria as well as their application in different immunotherapies. In addition, we further discuss the advantages and challenges of nanomaterial-engineered bacteria and their future prospects, inspiring more novel and intelligent tumor immunotherapy.
癌症仍然是全球人类死亡的主要原因。与传统疗法相比，肿瘤免疫疗法因其能够激活先天和适应性免疫、对正常组织毒性低以及具有长期免疫活性而受到广泛关注和研究。然而，由于免疫抑制微环境、缺乏时空控制、昂贵的成本和较长的制造时间，其临床效果和大规模应用受到限制。最近，纳米材料与工程菌的结合为肿瘤免疫治疗的挑战提供了一种很有前途的解决方案，该方案具有时空控制、逆转免疫抑制和可扩展生产的能力。因此，我们总结了纳米材料辅助工程菌在精确肿瘤免疫治疗中的最新研究进展，包括纳米材料与细菌的相互作用及其在不同免疫治疗中的应用。此外，我们进一步讨论了纳米材料-工程菌的优势和挑战及其未来前景，为更具创新性和智能性的肿瘤免疫治疗提供了灵感。
