Zhong Dayuan, Gan Zhenyu, Zheng Mengxue, Li Lan, Cheng Hui, Luo Hongsheng, Liu Deliang, Liu Pingwen, Li Huanjie, Ou Xueming, Deng Yihui
Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine of Guangzhou University of Chinese Medicine, Foshan, 528200, China.
Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Heliyon. 2023 Apr 26;9(5):e15828. doi: 10.1016/j.heliyon.2023.e15828. eCollection 2023 May.
The blood-brain barrier (BBB) is a natural physiological barrier that protects the central nervous system from foreign substances and limits the delivery of drugs to the brain. Nanotechnology has opened up new possibilities for drug delivery in the brain. Over several decades, various Nanoparticle Drug Delivery Systems (NDDS) that can cross the BBB have been developed for targeted delivery in the brain. To gain a comprehensive understanding of the current research hotspots and trends of NDDS across the BBB, this paper employs bibliometric analysis of articles published in the core database of Web of Science (WOS) from 1996 to 2022.
A search for relevant research literature on NDDS that can cross the BBB was conducted in the Web of Science database, covering the period from 1996 to 2022. The Bibliometrix R-4.0 software package was used to analyze data related to the countries of publication, research institutions, journals, citations, and keywords. The analysis aimed to identify the co-occurrence of keywords in the documents, including their titles and abstracts. Additionally, cooperative network analyses of authors, institutions, and countries of publication were conducted.
A total of 436 articles were analyzed, originating from 174 journals and 13 books, with the majority published in Q1 and Q2 journals. Contributors from 53 countries or regions participated in the publication of these articles, with China, the United States, and India having the highest number of articles by correspondent authors, and China, the United States, and Germany being the most cited countries. Fudan University, Hacettepe University, and Sichuan University were the top three institutions with the most publications. Among the 436 articles analyzed, 1337 keywords and 1450 keywords plus were identified. Factor analysis grouped the keywords plus into two categories: drug delivery systems, polymeric nanoparticles, gold nanoparticles, transferrin, and others, and drug, delivery, efficiency, expression, and mechanism.
The research on NDDS that can cross the BBB is gradually receiving attention, and the recognition and cooperation in this field have increased.
血脑屏障（BBB）是一种天然生理屏障，可保护中枢神经系统免受外来物质影响，并限制药物进入大脑。纳米技术为脑部药物递送开辟了新的可能性。几十年来，已开发出多种能够穿过血脑屏障的纳米颗粒药物递送系统（NDDS）用于脑部的靶向递送。为全面了解穿过血脑屏障的NDDS的当前研究热点和趋势，本文对1996年至2022年在科学网（WOS）核心数据库中发表的文章进行文献计量分析。
在科学网数据库中搜索1996年至2022年期间有关能够穿过血脑屏障的NDDS的相关研究文献。使用Bibliometrix R - 4.0软件包分析与发表国家、研究机构、期刊、引文和关键词相关的数据。该分析旨在识别文献（包括标题和摘要）中关键词的共现情况。此外，还对作者、机构和发表国家进行了合作网络分析。
共分析了436篇文章，这些文章来自174种期刊和13本书籍，其中大部分发表在Q1和Q2期刊上。来自53个国家或地区的作者参与了这些文章的发表，通讯作者文章数量最多的是中国、美国和印度，被引次数最多的国家是中国、美国和德国。复旦大学、哈杰泰佩大学和四川大学是发表文章数量最多的前三所机构。在分析的436篇文章中，识别出1337个关键词和1450个加关键词。因子分析将加关键词分为两类：药物递送系统、聚合物纳米颗粒、金纳米颗粒、转铁蛋白等，以及药物、递送、效率、表达和机制。
对能够穿过血脑屏障的NDDS的研究正逐渐受到关注，该领域的认可度和合作有所增加。
