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[过敏性肺炎的诊断与治疗——德国呼吸学会和德国变态反应与临床免疫学会S2k指南]

[Diagnosis and Treatment of Hypersensitivity Pneumonitis - S2k Guideline of the German Respiratory Society and the German Society for Allergology and Clinical Immunology].

作者信息

Koschel Dirk, Behr Jürgen, Berger Melanie, Bonella Francesco, Hamer Okka, Joest Marcus, Jonigk Danny, Kreuter Michael, Leuschner Gabriela, Nowak Dennis, Raulf Monika, Rehbock Beate, Schreiber Jens, Sitter Helmut, Theegarten Dirk, Costabel Ulrich

机构信息

Abteilung Innere Medizin und Pneumologie, Fachkrankenhaus Coswig, Lungenzentrum, Coswig, Deutschland.

Bereich Pneumologie, Medizinische Klinik 1, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Deutschland.

出版信息

Pneumologie. 2024 Dec;78(12):963-1002. doi: 10.1055/a-2369-8458. Epub 2024 Sep 3.

Abstract

Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease (ILD) in sensitized individuals caused by a large variety of inhaled antigens. The clinical form of acute HP is often misdiagnosed, while the chronic form, especially the chronic fibrotic HP, is difficult to differentiate from other fibrotic ILDs. The present guideline for the diagnosis and treatment of HP replaces the former German recommendations for the diagnosis of HP from 2007 and is amended explicitly by the issue of the chronic fibrotic form, as well as by treatment recommendations for the first time. The evidence was discussed by a multidisciplinary committee of experts. Then, recommendations were formulated for twelve questions on important issues of diagnosis and treatment strategies. Recently published national and international guidelines for ILDs and HP were considered. Detailed background information on HP is useful for a deeper insight into HP and the handling of the guideline.

摘要

过敏性肺炎(HP)是一种由多种吸入性抗原引起的、发生于致敏个体的免疫介导性间质性肺病(ILD)。急性HP的临床形式常被误诊,而慢性形式,尤其是慢性纤维化HP,很难与其他纤维化ILD区分开来。目前的HP诊断和治疗指南取代了2007年德国以前关于HP诊断的建议,并首次就慢性纤维化形式的问题以及治疗建议进行了明确修订。证据由一个多学科专家委员会进行了讨论。然后,针对诊断和治疗策略的重要问题的12个问题制定了建议。考虑了最近发布的关于ILD和HP的国家和国际指南。关于HP的详细背景信息有助于更深入地了解HP以及该指南的应用。

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