Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.
Shanxi Academy of Advanced Research and Innovation, Taiyuan 030032, China.
ACS Appl Mater Interfaces. 2024 Sep 18;16(37):48880-48894. doi: 10.1021/acsami.4c09623. Epub 2024 Sep 3.
Myocardial infarction (MI) is a serious cardiovascular disease with high morbidity and mortality rates, posing a significant threat to patient's health and quality of life. Following a MI, the damaged myocardial tissue is typically not fully repaired, leading to permanent impairment of myocardial function. While traditional treatments can alleviate symptoms and reduce pain, their ability to repair damaged heart muscle tissue is limited. Functionalized hydrogels, a broad category of materials with diverse functionalities, can enhance the properties of hydrogels to cater to the needs of tissue engineering, drug delivery, medical dressings, and other applications. Recently, functionalized hydrogels have emerged as a promising new therapeutic approach for the treatment of MI. Functionalized hydrogels possess outstanding biocompatibility, customizable mechanical properties, and drug-release capabilities. These properties enable them to offer scaffold support, drug release, and tissue regeneration promotion, making them a promising approach for treating MI. This paper aims to evaluate the advancements and delivery methods of functionalized hydrogels for treating MI, while also discussing their potential and the challenges they may pose for future clinical use.
心肌梗死（MI）是一种严重的心血管疾病，发病率和死亡率都很高，对患者的健康和生活质量构成重大威胁。MI 发生后，受损的心肌组织通常无法完全修复，导致心肌功能永久受损。虽然传统治疗可以缓解症状和减轻疼痛，但它们修复受损心肌组织的能力有限。功能化水凝胶是一类具有多种功能的广泛材料，可以增强水凝胶的性能，以满足组织工程、药物输送、医用敷料等应用的需求。最近，功能化水凝胶作为治疗 MI 的一种有前途的新治疗方法出现了。功能化水凝胶具有出色的生物相容性、可定制的机械性能和药物释放能力。这些特性使它们能够提供支架支撑、药物释放和组织再生促进作用，因此是治疗 MI 的一种很有前途的方法。本文旨在评估功能化水凝胶在治疗 MI 方面的最新进展和递送方法，同时讨论其潜在应用和未来临床应用可能面临的挑战。
