Science and Technology Innovation Platform Management Center of Jilin Province, Changchun, Jilin, 130000, China.
School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Curr Nutr Rep. 2024 Dec;13(4):679-690. doi: 10.1007/s13668-024-00568-2. Epub 2024 Sep 4.
Ischemic stroke is the second deadly disease worldwide, but current treatment is very limited. The brain, rich in lipids and high in oxygen consumption, is susceptible to damage from oxidative stress after ischemic stroke. Thus, antioxidants are promising neuroprotective agents for treatment and prevention of ischemic stroke. Coenzyme Q10 is the only lipophilic antioxidant that can be synthesized de novo by cells and plays a key role as an electron carrier in the oxidative phosphorylation of the mitochondrial electron transport chain. However, the reduced form of coenzyme Q10 (Ubiquinol) levels are significantly deficient in the brain. The aim of this article is to review the therapeutic effects and mechanisms of coenzyme Q10 in ischemic stroke.
Current studies have found that coenzyme Q10 protects and treats ischemic stroke through multiple mechanisms based on the evidence from in vitro experiments, in vivo experiments, and clinical observations. For the first time, we reviewed the neuroprotective effects of coenzyme Q10 in ischemic stroke. Coenzyme Q10 exerts neuroprotective effects after ischemic stroke through anti-oxidative stress, anti-nitrosative stress, anti-inflammation, and anti-cell death. Here, we provided the evidence on the therapeutic and preventive effects of coenzyme Q10 in ischemic stroke and suggested the potential value of coenzyme Q10 as a medication candidate.
缺血性脑卒中是全球第二大致死性疾病，但目前的治疗方法非常有限。大脑富含脂质，耗氧量高，易受缺血性脑卒中后氧化应激的损伤。因此，抗氧化剂是治疗和预防缺血性脑卒中很有前景的神经保护剂。辅酶 Q10 是唯一一种可由细胞从头合成的亲脂性抗氧化剂，在线粒体电子传递链氧化磷酸化过程中作为电子载体发挥关键作用。然而，辅酶 Q10 的还原形式（泛醇）在大脑中的水平显著不足。本文旨在综述辅酶 Q10 治疗缺血性脑卒中的疗效和作用机制。
目前的研究发现，辅酶 Q10 通过体外实验、体内实验和临床观察的证据，基于多种机制发挥保护和治疗缺血性脑卒中的作用。我们首次综述了辅酶 Q10 在缺血性脑卒中中的神经保护作用。辅酶 Q10 可通过抗氧化应激、抗亚硝基化应激、抗炎和抗细胞死亡来发挥其在缺血性脑卒中后的神经保护作用。在这里，我们提供了辅酶 Q10 治疗和预防缺血性脑卒中的疗效证据，并提出了辅酶 Q10 作为一种药物候选物的潜在价值。
