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无动力远程控制内窥机器人在复杂弯曲和局部区域进行可操纵和可编程成像。

Motor-free telerobotic endomicroscopy for steerable and programmable imaging in complex curved and localized areas.

机构信息

Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.

出版信息

Nat Commun. 2024 Sep 3;15(1):7680. doi: 10.1038/s41467-024-51633-x.

Abstract

Intraluminal epithelial abnormalities, potential precursors to significant conditions like cancer, necessitate early detection for improved prognosis. We present a motor-free telerobotic optical coherence tomography (OCT) endoscope that offers high-resolution intraluminal imaging and overcomes the limitations of traditional systems in navigating curved lumens. This system incorporates a compact magnetic rotor with a rotatable diametrically magnetized cylinder permanent magnet (RDPM) and a reflector, effectively mitigating thermal and electrical risks by utilizing an external magnetic field to maintain temperature increases below 0.5 °C and generated voltage under 0.02 mV. Additionally, a learning-based method corrects imaging distortions resulting from nonuniform rotational speeds. Demonstrating superior maneuverability, the device achieves steerable angles up to 110° and operates effectively in vivo, providing distortion-free 3D programmable imaging in mouse colons. This advancement represents a significant step towards guidewire-independent endomicroscopy, enhancing both safety and potential patient outcomes.

摘要

腔内上皮异常是癌症等重大疾病的潜在前体,需要早期检测以改善预后。我们提出了一种无动力远程机器人光学相干断层扫描(OCT)内窥镜,它提供了高分辨率的腔内成像,并克服了传统系统在导航弯曲管道方面的局限性。该系统采用了一个带有可旋转的径向往极化永磁体(RDPM)和反射镜的紧凑磁转子,通过利用外部磁场将温度升高保持在 0.5°C 以下,并将产生的电压控制在 0.02mV 以下,有效地降低了热和电的风险。此外,一种基于学习的方法可以校正由于非均匀转速引起的成像失真。该设备表现出卓越的操纵性能,可实现高达 110°的转向角度,并且在体内有效运行,可在小鼠结肠中提供无失真的 3D 可编程成像。这一进展是朝着无导丝内窥检查迈进的重要一步,提高了安全性和潜在的患者治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b232/11372151/9f9b66578926/41467_2024_51633_Fig2_HTML.jpg

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