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Genome-wide CRISPR/Cas9 library screening identified OGDH as a regulator of disease progress and resistance to decitabine in myelodysplastic neoplasm by reprogramming glutamine metabolism.

作者信息

Xu Xiaoyan, Qi Jiaqian, Wang Hong, Zhang Ziyan, Pan Tingting, Li Xueqian, Yang Jingyi, Han Haohao, Guo Mengting, Zhou Meng, Cai Chengsen, Tang Yaqiong, Hou Qixiu, Chen Suning, Wu Depei, Han Yue

机构信息

National clinical research center for hematologic diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.

出版信息

Leukemia. 2024 Nov;38(11):2505-2509. doi: 10.1038/s41375-024-02377-6. Epub 2024 Sep 3.

DOI:10.1038/s41375-024-02377-6
PMID:39227691
Abstract
摘要

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本文引用的文献

1
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.世界卫生组织血液淋巴肿瘤分类第五版：髓系和组织细胞/树突状肿瘤。
Leukemia. 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. Epub 2022 Jun 22.
2
NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 3.2022.美国国立综合癌症网络（NCCN）指南见解：骨髓增生异常综合征，2022年第3版
J Natl Compr Canc Netw. 2022 Feb;20(2):106-117. doi: 10.6004/jnccn.2022.0009.
3
Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies.
用于治疗急性髓系白血病和骨髓增生异常综合征的低甲基化剂（HMA）：耐药机制和新型基于 HMA 的治疗方法。
Leukemia. 2021 Jul;35(7):1873-1889. doi: 10.1038/s41375-021-01218-0. Epub 2021 May 6.
4
A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease.OGDH基因中的双等位基因致病性变异导致一种具有线粒体疾病特征的神经障碍。
J Inherit Metab Dis. 2021 Mar;44(2):388-400. doi: 10.1002/jimd.12248. Epub 2020 Jun 24.
5
Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies.靶向代谢中间产物增强 BH3 模拟物治疗血液系统恶性肿瘤的疗效。
Haematologica. 2019 May;104(5):1016-1025. doi: 10.3324/haematol.2018.204701. Epub 2018 Nov 22.
6
Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.病态造血相关的假缺氧作为骨髓增生异常综合征的潜在机制。
Cancer Discov. 2018 Nov;8(11):1438-1457. doi: 10.1158/2159-8290.CD-17-1203. Epub 2018 Aug 23.
7
Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism.化疗耐药的人类急性髓系白血病细胞并非富含白血病干细胞，但需要氧化代谢。
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