Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ital J Pediatr. 2024 Sep 4;50(1):163. doi: 10.1186/s13052-024-01728-4.
Systemic Lupus Erythematosus (SLE) patients are more likely than the general population to suffer from thyroid illness. The major goal was to assess the thyroid dysfunctions due to immunological factors in Egyptian SLE children and how they are related to the course and severity of the illness.
Fifty children and adolescents with SLE are included in this cross-sectional observational study. Every patient underwent a thorough physical examination and a comprehensive history taking. An enzyme-linked immunosorbent assay (ELISA) approach was used to evaluate the thyroid profile, anti-thyroglobulin (Anti-TG), and anti-thyroid peroxidase (anti-TPO) antibodies.
Of the 50 patients, the female: male ratio (F: M = 7:1) was 44 females and 6 males (12%). They were between the ages of 5 and 17. Out of the patients, thirty-two (64%) had thyroid dysfunctions, 19 (38%) had euthyroid sick syndrome, ten (20%) had overt hypothyroidism, three (6%) had subclinical hypothyroidism, and none had hyperthyroidism. Of the 50 patients, one (2%) had increased anti-TPO, whereas all other patients had normal anti-TG levels. A statistically significant negative correlation (p-value 0.007) was seen between the disease duration and free thyroxine (FT4). Furthermore, a significant negative correlation (p-values 0.015 and 0.028) was found when comparing the disease duration with thyroid antibodies (anti-TG and anti-TPO).
In Juvenile Systemic Lupus Erythematosus (JSLE), thyroid dysfunctions can be identified. The disease duration but not its activity was significantly correlated with thyroid antibodies. For children with JSLE, thyroid function testing should be done on a regular basis. It is preferable to carry out additional thyroid antibody tests when necessary.
红斑狼疮（SLE）患者比一般人群更容易患甲状腺疾病。主要目的是评估埃及 SLE 儿童的免疫因素引起的甲状腺功能障碍，以及它们与疾病的病程和严重程度的关系。
本横断面观察性研究纳入了 50 名 SLE 儿童和青少年患者。每位患者均接受了详细的体格检查和全面的病史采集。采用酶联免疫吸附试验（ELISA）方法评估甲状腺功能谱、抗甲状腺球蛋白（Anti-TG）和抗甲状腺过氧化物酶（anti-TPO）抗体。
50 例患者中，女性：男性比例（F：M=7：1）为 44 例女性和 6 例男性（12%）。年龄在 5 至 17 岁之间。32 例（64%）患者存在甲状腺功能障碍，19 例（38%）存在甲状腺功能正常的病态综合征，10 例（20%）存在显性甲状腺功能减退症，3 例（6%）存在亚临床甲状腺功能减退症，无患者存在甲状腺功能亢进症。50 例患者中，1 例（2%）抗 TPO 升高，而所有其他患者抗 TG 水平正常。疾病持续时间与游离甲状腺素（FT4）之间存在显著负相关（p 值 0.007）。此外，疾病持续时间与甲状腺抗体（抗 TG 和抗 TPO）之间的比较显示出显著负相关（p 值分别为 0.015 和 0.028）。
在幼年系统性红斑狼疮（JSLE）中，可以发现甲状腺功能障碍。疾病持续时间而非其活动度与甲状腺抗体显著相关。对于患有 JSLE 的儿童，应定期进行甲状腺功能检查。必要时，最好进行额外的甲状腺抗体检测。
