Mir Tanveer Ahmad, Iwanaga Shintaroh, Kurooka Taketoshi, Toda Hideki, Sakai Shinji, Nakamura Makoto
Graduate School of Science and Engineering for Research (Engineering), University of Toyama, Toyama 930-8555, Japan.
Toyama Nanotechnology Manufacturing Cluster, Toyama, Japan.
Int J Bioprint. 2018 Dec 31;5(1):153. doi: 10.18063/ijb.v5i1.153. eCollection 2019.
Biofabrication is an emerging multidisciplinary field that makes a revolutionary impact on the researches on life science, biomedical engineering, and both basic and clinical medicine, has progressed tremendously over the past few years. Recently, there has been a big boom in three-dimensional (3D) printing or additive manufacturing (AM) research worldwide, and there is a significant increase not only in the number of researchers turning their attention to AM but also publications demonstrating the potential applications of 3D printing techniques in multiple fields. Biofabrication and bioprinting hold great promise for the innovation of engineering-based organ replacing medicine. In this mini review, various challenges in the field of tissue engineering are focused from the point of view of the biofabrication - strategies to bridge the gap between organ shortage and mission of medical innovation research seek to achieve organ-specific treatments or regenerative therapies. Four major challenges are discussed including (i) challenge of producing organs by AM, (ii) digitalization of tissue engineering and regenerative medicine, (iii) rapid production of organs beyond the biological natural course, and (iv) extracorporeal organ engineering.
生物制造是一个新兴的多学科领域，对生命科学、生物医学工程以及基础医学和临床医学研究产生了革命性影响，在过去几年中取得了巨大进展。最近，全球范围内三维（3D）打印或增材制造（AM）研究蓬勃发展，不仅关注AM的研究人员数量大幅增加，而且展示3D打印技术在多个领域潜在应用的出版物也显著增多。生物制造和生物打印在基于工程的器官替代医学创新方面具有巨大潜力。在这篇小型综述中，从生物制造的角度聚焦了组织工程领域的各种挑战——弥合器官短缺与医学创新研究使命之间差距的策略旨在实现器官特异性治疗或再生疗法。讨论了四个主要挑战，包括（i）通过增材制造生产器官的挑战，（ii）组织工程和再生医学的数字化，（iii）超越生物自然过程快速生产器官，以及（iv）体外器官工程。
