Angus Lachlan M, Mikołajczyk Maksym, Cheung Ada S, Kasielska-Trojan Anna K
From the Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.
Plastic, Reconstructive and Aesthetic Surgery Clinic, Medical University of Łódź, Łódź, Poland.
Plast Reconstr Surg Glob Open. 2024 Sep 3;12(9):e6131. doi: 10.1097/GOX.0000000000006131. eCollection 2024 Sep.
Accurate estimation of breast volume is important as researchers aim to achieve optimal feminization for transfeminine people. The Breast Idea Volume Estimator (BIVE) application allows estimation of breast volume using two-dimensional (2D) photographs but has not been validated in the chests of people who have undergone testosterone-mediated puberty.
To estimate breast volume, clinical photographs and 3D scans were collected at baseline and 6 months, as a prespecified secondary outcome of a randomized clinical trial of antiandrogen therapy in transfeminine people commencing hormone therapy. BIVE was used to estimate breast volume by two independent researchers and compared with the gold standard of 3D scan calculated volume at different timepoints. Statistical analysis was performed, including the mean absolute difference, standard error of measurement, and intraclass correlation, to determine accuracy, precision, and interrater agreement.
Clinical photography and 3D scans were collected from 82 breasts of 41 participants. The median (interquartile range) age of participants was 25 (22-28) years, and the median (interquartile range) body mass index was 24.6 (21.2-28.9) kg/m. The BIVE sagittal and transverse algorithms demonstrated robust performance, with mean absolute difference less than 20 mL and intraclass correlation greater than 0.87 indicating clinical reliability with high interrater agreement.
BIVE provided an accurate, precise, and reliable measure of breast volume in the chests of people who have undergone testosterone-mediated puberty, compared with the gold standard of 3D scan.
准确估计乳房体积很重要，因为研究人员旨在为跨性别女性实现最佳女性化效果。乳房理想体积估计器（BIVE）应用程序可使用二维（2D）照片估计乳房体积，但尚未在经历过睾酮介导青春期的人群胸部得到验证。
作为一项针对开始激素治疗的跨性别女性抗雄激素治疗随机临床试验的预先指定次要结果，在基线和6个月时收集临床照片和3D扫描数据以估计乳房体积。由两名独立研究人员使用BIVE估计乳房体积，并与不同时间点3D扫描计算体积的金标准进行比较。进行了统计分析，包括平均绝对差、测量标准误差和组内相关性，以确定准确性、精密度和评分者间一致性。
从41名参与者的82个乳房收集了临床照片和3D扫描数据。参与者的年龄中位数（四分位间距）为25（22 - 28）岁，体重指数中位数（四分位间距）为24.6（21.2 - 28.9）kg/m²。BIVE矢状面和横断面算法表现出稳健的性能，平均绝对差小于20毫升，组内相关性大于0.87，表明具有临床可靠性且评分者间一致性高。
与3D扫描的金标准相比，BIVE为经历过睾酮介导青春期的人群胸部乳房体积提供了准确、精确且可靠的测量方法。
