Irifune Satoshi, Ide Shotaro, Koga Satoru, Mine Keisuke, Sugasaki Nanae, Kosai Kosuke, Fukuda Minoru, Yanagihara Katsunori, Mukae Hiroshi
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.
Department of Respiratory Medicine, Nagasaki Prefecture Shimabara Hospital, Nagasaki, JPN.
Cureus. 2024 Aug 4;16(8):e66137. doi: 10.7759/cureus.66137. eCollection 2024 Aug.
, a novel species discovered in Japan in 2023, has not been reported to infect humans. Here, we report a case of pulmonary nocardiosis in a 70-year-old immunocompetent woman infected with . The patient presented to the hospital with a chief complaint of weight loss. She worked at a fruit sorting facility where she was exposed to dust. Chest computed tomography revealed a single cavity and diffuse nodular opacities in both lungs. species was isolated from tracheal sputum and bronchial lavage fluid and identified as via 16S rRNA gene sequencing. The patient was treated with oral sulfamethoxazole and trimethoprim but developed oral mucositis on the 12th day of treatment. Consequently, minocycline was prescribed, and the patient's condition improved after a six-month course of treatment. To our knowledge, this is the first reported case of pulmonary nocardiosis caused by in humans. Accurate species identification and antimicrobial susceptibility tests will be necessary to prescribe appropriate treatment for infections.
于2023年在日本发现的一个新物种尚未有感染人类的报道。在此，我们报告一例70岁免疫功能正常的女性感染该物种后发生肺诺卡菌病的病例。患者因体重减轻为主诉入院。她在一家水果分拣厂工作，在那里接触灰尘。胸部计算机断层扫描显示双肺有单个空洞和弥漫性结节状混浊。从气管痰液和支气管灌洗液中分离出该物种，并通过16S rRNA基因测序鉴定为该物种。患者接受口服磺胺甲恶唑和甲氧苄啶治疗，但在治疗第12天出现口腔粘膜炎。因此，开具了米诺环素，经过六个月的治疗疗程后患者病情好转。据我们所知，这是首例人类感染该物种导致肺诺卡菌病的报道病例。准确的物种鉴定和抗菌药敏试验对于为该物种感染开具适当治疗方案是必要的。
