Liu Yu, Mei Xue, Qian Zhiping, Yuan Wei, Wang Jiefei, Ji Liujuan, Zeng Dong, Zhou Yanli, Zhang Yuyi
Department of Liver Intensive Care Unit, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Department of Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Heliyon. 2024 Aug 10;10(16):e36128. doi: 10.1016/j.heliyon.2024.e36128. eCollection 2024 Aug 30.
Thrombocytopenia, anasarca, fever, reticulin fibrosis on bone marrow biopsy/renal dysfunction, and organomegaly (TAFRO) syndrome are infrequent conditions with diverse clinical and pathological characteristics related to multi-organ damage. There are few reports of TAFRO syndrome accompanied by liver damage with hyperbilirubinemia. We describe the case of a 61-year-old male who presented with sudden onset abdominal pain accompanied by liver damage with hyperbilirubinemia. His symptoms worsened, leading to fever, hepatic insufficiency, serous cavity effusions, thrombocytopenia, and acute renal failure. Fever and anasarca relapsed after steroid discontinuation. The patient was ultimately diagnosed with TAFRO syndrome by biopsies taken from the axillary lymph nodes. He was then administered steroids, which resolved his symptoms almost completely. Our case was notable for its atypical signs and total remission of TAFRO syndrome.
血小板减少、全身性水肿、发热、骨髓活检显示网状纤维增生/肾功能不全以及器官肿大（TAFRO）综合征是罕见病症，具有与多器官损害相关的多样临床和病理特征。关于TAFRO综合征伴有高胆红素血症性肝损害的报道很少。我们描述了一名61岁男性病例，该患者突发腹痛并伴有高胆红素血症性肝损害。其症状加重，导致发热、肝功能不全、浆膜腔积液、血小板减少和急性肾衰竭。停用类固醇后发热和全身性水肿复发。最终通过腋窝淋巴结活检确诊该患者患有TAFRO综合征。随后给予其类固醇治疗，症状几乎完全缓解。我们的病例以其非典型体征和TAFRO综合征完全缓解而引人注目。
