类菌素在 2 型糖尿病患者中的作用。

THE ROLE OF MYONECTIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.

机构信息

1College of Science, Tikrit University, Iraq.

2Department of Biochemistry, College of Medicine, University of Tikrit, Iraq.

出版信息

Georgian Med News. 2024 Jun(351):96-99.

PMID:39230229

Abstract

BACKGROUND

Diabetes is a chronic devastating disease characterized by remarkable tissue damage.

AIM

This prospective study conducted in Tikrit City aimed to investigate the role of myonectin and glycemic control parameters in type 2 diabetes (T2DM).

METHODS

The study enrolled 60 patients with T2DM and 30 controls participants. Blood withdrawn, serum separated, serum myonectin and glycemic control parameters were quantified using Cobas C 111 analyzer. The mean serum level FBS (263.60±130.83) and HbA1C (97.56±15.54%) in T2DM patients compared with the control group (p≤0.0001). Myonectin level (pg/ml) significantly reduced (p>0.005) in T2DM (292.78±110.32) compared with the control group (379.72±140.64).

CONCLUSIONS

Circulating myonectin levels were decreased in T2DM patients. Moreover, serum myonectin levels were correlated with metabolic markers of T2DM. These data suggest that myonectin may be a useful marker in predicting the development of T2DM.

摘要

背景

糖尿病是一种慢性破坏性疾病，其特征是显著的组织损伤。

目的

本前瞻性研究在提克里特市进行，旨在探讨肌联蛋白和血糖控制参数在 2 型糖尿病（T2DM）中的作用。

方法

该研究纳入了 60 例 T2DM 患者和 30 名对照参与者。抽取血液，分离血清，使用 Cobas C 111 分析仪定量测定血清肌联蛋白和血糖控制参数。与对照组相比，T2DM 患者的平均血清 FBS（263.60±130.83）和 HbA1C（97.56±15.54%）水平更高（p≤0.0001）。与对照组（379.72±140.64）相比，T2DM 患者的肌联蛋白水平（pg/ml）显著降低（p>0.005）。