School of Public Health, Chongqing Medical University, Chongqing, China.
Eur J Clin Microbiol Infect Dis. 2024 Nov;43(11):2127-2135. doi: 10.1007/s10096-024-04933-5. Epub 2024 Sep 4.
This study aimed to investigate Human papillomavirus (HPV) infection and genotyping in men from Chongqing and analyze age-related trends to provide insights for HPV prevention and vaccination plans tailored for men in Chongqing, China.
This study is an observational study. We investigated male patients who underwent HPV screening at two hospitals in Chongqing from 2017 to 2022, totaling 4,381 cases, aged 18 to 85. HPV genotyping was conducted using the Hybribio Rapid GenoArray kit.
Among the 4,381 men, the overall HPV prevalence was 14.9%, peaking at 19.3% in 2022. Single HPV infection was 11.5%, and multiple infection was 3.4%. The most prevalent genotypes were HPV-52, HPV-16, and HPV-58. Single high-risk HPV infection peaked in the 36-45 age group, while multiple high-risk HPV infection decreased with age (P-trend < 0.01). Prevalence in the ≤ 25 age group was 3.7%. Single low-risk HPV infection also decreased with age (P-trend = 0.03). Genotypes covered by the nonavalent vaccine had the highest prevalence, increasing with age. Co-infection of HPV-16 with HPV-52 and HPV-58 was common. Single HPV infections were prevalent in cases of urethritis (30.8%), anogenital warts (36.4%), and genital warts (26.3%), while multiple HPV infections were significant in anogenital warts (18.2%).
Single HPV infection was predominant in Chongqing, with HPV-52, HPV-16, HPV-58, HPV-53, and HPV-39 being the most prevalent genotypes. The prevalence of genotypes covered by the nonavalent vaccine increased with age. This study offers valuable insights for developing male-specific HPV prevention strategies in Chongqing.
本研究旨在调查重庆地区男性人群人乳头瘤病毒（HPV）感染和基因型分布，并分析其年龄相关性趋势，为重庆市男性 HPV 预防和疫苗接种计划提供参考。
本研究为观察性研究。我们调查了 2017 年至 2022 年期间在重庆两家医院进行 HPV 筛查的男性患者，共 4381 例，年龄 18 至 85 岁。采用 Hybribio Rapid GenoArray 试剂盒进行 HPV 基因分型。
在 4381 名男性中，HPV 总感染率为 14.9%，2022 年达到峰值 19.3%。单一 HPV 感染率为 11.5%，多重感染率为 3.4%。最常见的基因型为 HPV-52、HPV-16 和 HPV-58。单一高危型 HPV 感染在 36-45 岁年龄组达到高峰，而多重高危型 HPV 感染随年龄增长而降低（P 趋势 < 0.01）。≤25 岁年龄组的感染率为 3.7%。单一低危型 HPV 感染也随年龄增长而降低（P 趋势 = 0.03）。九价疫苗涵盖的基因型感染率最高，且随年龄增长而增加。HPV-16 与 HPV-52 和 HPV-58 的共同感染较为常见。单一 HPV 感染在尿道炎（30.8%）、肛门生殖器疣（36.4%）和生殖器疣（26.3%）中更为常见，而多重 HPV 感染在肛门生殖器疣（18.2%）中更为显著。
重庆地区以单一 HPV 感染为主，HPV-52、HPV-16、HPV-58、HPV-53 和 HPV-39 为最常见的基因型。九价疫苗涵盖的基因型感染率随年龄增长而增加。本研究为重庆市制定男性 HPV 特异性预防策略提供了有价值的信息。
