Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Environ Res. 2024 Dec 1;262(Pt 2):119916. doi: 10.1016/j.envres.2024.119916. Epub 2024 Sep 2.
Bixafen (BIX), a member of the succinate dehydrogenase inhibitor (SDHI) class of fungicides, has seen a surge in interest due to its expanding market presence and positive development outlook. However, there is a growing concern about its potential harm to aquatic life, largely due to its resistance to breaking down in the environment. In this study, we thoroughly examined the toxicological impact of BIX on zebrafish as a model organism. Our results revealed that BIX significantly hindered the development of zebrafish embryos, leading to increased mortality, hatching failures, and oxidative stress. Additionally, we observed cardiovascular abnormalities, including dilated cardiac chambers, reduced heart rate, sluggish blood circulation, and impaired vascular function. Notably, BIX also altered the expression of key genes involved in cardiovascular development, such as myl7, vmhc, nkx2.5, tbx5, and flt1. In summary, BIX was found to induce developmental and cardiovascular toxicity in zebrafish, underscoring the risks associated with SDHI pesticides and emphasizing the need for a reassessment of their impact on human health. These findings are crucial for the responsible use of BIX.
双酰胺类杀菌剂中的一员，由于其市场占有率的扩大和积极的发展前景，啶酰菌胺（BIX）引起了人们的极大关注。然而，人们越来越担心它可能对水生生物造成危害，这主要是因为它在环境中难以降解。在这项研究中，我们深入研究了 BIX 对斑马鱼这一模式生物的毒理学影响。结果表明，BIX 显著阻碍了斑马鱼胚胎的发育，导致死亡率增加、孵化失败和氧化应激。此外，我们观察到心血管异常，包括心脏腔室扩张、心率降低、血液循环缓慢和血管功能受损。值得注意的是，BIX 还改变了参与心血管发育的关键基因的表达，如 myl7、vmhc、nkx2.5、tbx5 和 flt1。总之，BIX 被发现会在斑马鱼体内引起发育和心血管毒性，这突显了 SDHI 类农药所带来的风险，并强调了重新评估它们对人类健康影响的必要性。这些发现对于 BIX 的合理使用至关重要。
