Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China; Key Laboratory of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai 200032, China.
Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
Sci Total Environ. 2024 Nov 25;953:175958. doi: 10.1016/j.scitotenv.2024.175958. Epub 2024 Sep 2.
A burgeoning body of epidemiological and toxicological evidence suggests that thyroid health may be significantly impacted by exposure to both long- and short-chain perfluoroalkyl substances (PFAS) compounds. We conducted a meta-analysis to examine the association between 16 PFAS compounds and five thyroid hormones (TSH, TT3, TT4, FT3, and FT4) in the serum of a pregnant women, adolescents, and adults. The dose-response relationship between some PFAS and thyroid hormones in different population subpopulation was found and the model was fitted. We also amalgamated data from 18 animal experiments with previously published in vitro studies to elucidate the toxicological mechanisms underlying the impact of PFAS on the thyroid gland. The results of the study showed that (a) both conventional and emerging PFAS compounds were identified in human samples and exhibited associations with thyroid health outcomes; (b) in animal studies, PFAS have been found to impact thyroid gland health through two primary mechanisms: by influencing the hypothalamic-pituitary-thyroid axis and by binding to thyroid receptors. This study provides a systematic description of the health effects and risk assessment associated with PFAS exposure on the thyroid gland. Furthermore, dose-response relationships were established through the Hill model in python.
越来越多的流行病学和毒理学证据表明，甲状腺健康可能会受到长链和短链全氟烷基物质 (PFAS) 化合物的显著影响。我们进行了一项荟萃分析，以研究 16 种 PFAS 化合物与孕妇、青少年和成年人血清中的五种甲状腺激素（TSH、TT3、TT4、FT3 和 FT4）之间的关联。我们发现了一些 PFAS 与不同人群甲状腺激素之间的剂量-反应关系，并拟合了模型。我们还综合了 18 项动物实验的数据和之前发表的体外研究，以阐明 PFAS 对甲状腺影响的毒理学机制。研究结果表明：(a) 人类样本中既检测到传统的 PFAS 化合物，也检测到新兴的 PFAS 化合物，且它们与甲状腺健康结果有关联；(b) 在动物研究中，PFAS 已被发现通过两种主要机制影响甲状腺健康：通过影响下丘脑-垂体-甲状腺轴，以及通过与甲状腺受体结合。本研究系统描述了与 PFAS 暴露相关的甲状腺健康影响和风险评估。此外，还通过 python 中的 Hill 模型建立了剂量-反应关系。
