黄曲霉毒素B1、柄曲霉素和杂色曲霉素的量子化学研究及其诱变活性比较
Quantum-chemical studies of aflatoxin B1, sterigmatocystin and versicolorin A, and a comparison with their mutagenic activity.
作者信息
Pachter R, Steyn P S
出版信息
Mutat Res. 1985 May-Jun;143(1-2):87-91. doi: 10.1016/0165-7992(85)90111-3.
PMID:3923331
Abstract
The INDO atomic charges q and Wiberg bond indices p (in electrons) were calculated for aflatoxin B1, sterigmatocystin and versicolorin A. The C-2-C-3 bond in these compounds has the same bond order and is predicted to be the most reactive towards epoxidation. The electronic effects do not explain the observed differences in mutagenicity and toxicity.
摘要
计算了黄曲霉毒素B1、柄曲霉素和杂色曲霉素A的INDO原子电荷q和维伯格键级p（以电子为单位）。这些化合物中的C-2-C-3键具有相同的键级，预计对环氧化反应最具反应活性。电子效应无法解释所观察到的致突变性和毒性差异。
相似文献
1
Quantum-chemical studies of aflatoxin B1, sterigmatocystin and versicolorin A, and a comparison with their mutagenic activity.黄曲霉毒素B1、柄曲霉素和杂色曲霉素的量子化学研究及其诱变活性比较
Mutat Res. 1985 May-Jun;143(1-2):87-91. doi: 10.1016/0165-7992(85)90111-3.
2
Hepatocarcinogenicity of sterigmatocystin and versicolorin A to rainbow trout (Salmo gairdneri) embryos.柄曲霉素和杂色曲霉素对虹鳟（萨氏虹鳟）胚胎的肝致癌性。
J Natl Cancer Inst. 1980 Jun;64(6):1503-9. doi: 10.1093/jnci/64.6.1503.
3
Metabolism of versicolorin A, a genotoxic precursor of aflatoxin B1: Characterization of metabolites using in vitro production of standards.黄曲霉素 B1 的遗传毒性前体物质威豆菌素 A 的代谢：利用体外生成标准品来对代谢物进行特征描述。
Food Chem Toxicol. 2022 Sep;167:113272. doi: 10.1016/j.fct.2022.113272. Epub 2022 Jul 6.
4
5
Genotoxicity of aflatoxins and their precursors in human cells.黄曲霉毒素及其前体在人体细胞中的遗传毒性。
Toxicol Lett. 2018 May 1;287:100-107. doi: 10.1016/j.toxlet.2018.02.007. Epub 2018 Feb 5.
6
Biological reactive intermediates of bisfuranoid mycotoxins.双呋喃类霉菌毒素的生物活性中间体。
J Toxicol Sci. 1990 Dec;15 Suppl 4:152-8. doi: 10.2131/jts.15.supplementiv_152.
7
Precursor recognition by kinetic pulse-labeling in a toxigenic aflatoxin B1-producing strain of Aspergillus.在产毒黄曲霉毒素B1的黄曲霉菌株中通过动力学脉冲标记进行前体识别。
Appl Environ Microbiol. 1981 Jul;42(1):168-73. doi: 10.1128/aem.42.1.168-173.1981.
8
Appearance of enzyme activities catalyzing conversion of sterigmatocystin to aflatoxin B1 in late-growth-phase Aspergillus parasiticus cultures.在寄生曲霉培养物生长后期，催化柄曲霉素转化为黄曲霉毒素B1的酶活性的出现。
Appl Environ Microbiol. 1987 Jul;53(7):1711-3. doi: 10.1128/aem.53.7.1711-1713.1987.
9
The conversion of sterigmatocystin to O-methylsterigmatocystin and aflatoxin B1 by a cell-free preparation.通过无细胞制剂将柄曲霉素转化为 O-甲基柄曲霉素和黄曲霉毒素 B1。
Biochem Biophys Res Commun. 1983 Nov 15;116(3):1114-8. doi: 10.1016/s0006-291x(83)80257-5.
引用本文的文献
1
Computational Studies of Aflatoxin B (AFB): A Review.计算研究黄曲霉毒素 B (AFB)：综述。
Toxins (Basel). 2023 Feb 7;15(2):135. doi: 10.3390/toxins15020135.
2
Synthesis of sterigmatocystin on a chemically defined medium by species of Aspergillus and Chaetomium.曲霉属和毛壳菌属菌种在化学成分明确的培养基上合成柄曲霉素。
Mycopathologia. 1994 Mar;125(3):173-8. doi: 10.1007/BF01146523.
Zotero 插件