Theodorakopoulou Elina, Aguilera Shino Bay, Duncan Diane Irvine
Aesthet Surg J Open Forum. 2024 Aug 9;6:ojae060. doi: 10.1093/asjof/ojae060. eCollection 2024.
Facial dyspigmentation is a challenging concern which cannot easily be corrected. Although the application of topical exosomes has shown some efficacy, there is still scarce data addressing the role of plant-derived exosomes for skin hyperpigmentation.
This study using rose stem-cell-derived exosomes (RSCE) was performed as a proof-of-concept case series to evaluate the efficacy and safety of microneedling and topical RSCE, for the reduction of pigmentation and photoaging in adult volunteers.
Twelve female volunteers were recruited, with a mean age of 46.64 years and a moderate-to-severe facial pigmentation, due to solar lentigines, melasma, postinflammatory hyperpigmentation, and periorbital hyperpigmentation. Three treatments were performed at 3 weeks intervals. These consisted of the topical application of RSCE with microneedling and a 20 min LED light with an RSCE-infused mask. A 3D facial analyzer was used to quantify improvement in superficial, deep pigmentation, skin redness, and wrinkles at baseline, Weeks 3, 6, and 12. Global Aesthetic Improvement Scale (GAIS), Dermatology Life and Quality Index (DLQI), and Melasma Quality of Life Scale (MELASQoL) scores were noted at the same time points.
GAIS scores improved by at least 1 scale point. Superficial pigmentation and spots decreased by 12.95% and deep pigmentation improved by 15.9%, by Week 12. Skin redness was reduced by 7.34% at the same time point. The measured wrinkle reduction was 6.34%. DLQI scores were reduced by 10 points, and MELASQoL scores had a mean reduction of 30 points at Week 12.
Improvement of facial pigmentation is possible when combining nonthermal microneedling and the use of topical RSCE.
面部色素沉着是一个具有挑战性的问题，难以轻易纠正。尽管局部应用外泌体已显示出一定疗效，但关于植物源性外泌体对皮肤色素沉着作用的数据仍然稀缺。
本研究使用玫瑰干细胞衍生的外泌体（RSCE）作为概念验证病例系列，以评估微针和局部应用RSCE对成年志愿者减少色素沉着和光老化的疗效和安全性。
招募了12名女性志愿者，平均年龄46.64岁，面部有中度至重度色素沉着，原因包括日光性雀斑、黄褐斑、炎症后色素沉着和眶周色素沉着。每隔3周进行一次治疗。治疗包括微针联合局部应用RSCE以及使用注入RSCE的面膜进行20分钟的LED光照。在基线、第3周、第6周和第12周，使用3D面部分析仪量化浅表、深层色素沉着、皮肤发红和皱纹的改善情况。同时记录全球美学改善量表（GAIS）、皮肤病生活质量指数（DLQI）和黄褐斑生活质量量表（MELASQoL）评分。
GAIS评分至少提高了1个等级。到第12周时，浅表色素沉着和斑点减少了12.95%，深层色素沉着改善了15.9%。同一时间点皮肤发红减少了7.34%。测得的皱纹减少了6.34%。第12周时，DLQI评分降低了10分，MELASQoL评分平均降低了30分。
联合非热微针和局部应用RSCE可改善面部色素沉着。
