Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Lasers Med Sci. 2020 Sep;35(7):1599-1606. doi: 10.1007/s10103-020-03008-z. Epub 2020 Apr 17.
Traditional attempts at alleviating photoaging-associated facial pigmentation conditions such as melasma, mottled hyperpigmentation, and post-inflammatory hyperpigmentation have yielded disfiguring cosmetic results. Laser toning using a low-fluence Q-switched 1064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser has been more commonly applied to date. However, the treatment efficacy and safety of this approach have not been widely reported. This study therefore evaluated the efficacy and safety of picosecond 1064-nm Nd:YAG laser application for photoaging-associated facial pigmentation treatment in Korean subjects. Forty-seven Korean subjects with photoaging-associated facial pigmentation underwent picosecond 1064-nm laser application. The clinical improvement of 17 patients was assessed by objective measurements such as melanin and erythema indices. All subjects received six biweekly treatments with the laser in a three-pass fashion delivering approximately 2000 to 2500 shots using a zoom handpiece with a spot size of 7 mm, fluence ranging from 0.4 to 0.7 J/cm, and a repetition rate of 10 Hz. Clinicians evaluated the improvement of pigmentation using the pigmentation area and severity index (PSI), and subjects reported their satisfaction level on a four-point scale. Statistical analyses were performed using the SPSS version 19.0 for Windows software program (IBM Corp., Armonk, NY, USA). Forty-seven subjects (45 females and two males) completed this study with a 12-week follow-up period. The average decrease in PSI value at 12 weeks after treatment was 6.85 ± 6.35 points (p < 0.001). The average decreases in the values of the erythema and melanin indices were 19.41 ± 64.64 points (p = 0.234) and 28.88 ± 32.89 points (p = 0.002). An analysis of 32 subjects' reports (68.1%) suggested good or excellent improvement. No serious adverse effects were observed during treatment or the follow-up period. Picosecond 1064-nm Nd:YAG laser application appears to be safe and effective in improving various photoaging-associated facial pigmentation conditions in Korean skin.
传统的缓解光老化相关面部色素沉着的方法，如黄褐斑、斑驳性色素沉着和炎症后色素沉着，会产生毁容的美容效果。迄今为止，更常应用低能量 Q 开关 1064nm 掺钕钇铝石榴石（Nd:YAG）激光进行激光调谐。然而，这种方法的治疗效果和安全性尚未得到广泛报道。因此，本研究评估了皮秒 1064nmNd:YAG 激光治疗韩国患者光老化相关面部色素沉着的疗效和安全性。47 例光老化相关面部色素沉着的韩国患者接受皮秒 1064nm 激光治疗。17 例患者的临床改善情况通过黑素和红斑指数等客观指标进行评估。所有患者均接受 6 次双周激光治疗，采用三通道方式，使用 7mm 变焦手柄，光斑大小为 7mm，能量范围为 0.4 至 0.7J/cm，重复频率为 10Hz，共发射约 2000 至 2500 个激光脉冲。临床医生使用色素沉着面积和严重程度指数（PSI）评估色素沉着的改善情况，患者则根据 4 分制报告其满意度。使用 SPSS 版本 19.0 for Windows 软件程序（IBM 公司，纽约州阿蒙克）进行统计学分析。47 例患者（45 名女性和 2 名男性）完成了这项为期 12 周的研究，并进行了 12 周的随访。治疗后 12 周时 PSI 值的平均下降幅度为 6.85±6.35 分（p<0.001）。红斑和黑素指数值的平均下降幅度分别为 19.41±64.64 分（p=0.234）和 28.88±32.89 分（p=0.002）。对 32 例患者报告（68.1%）的分析表明，改善情况良好或极好。治疗期间和随访期间均未观察到严重不良反应。皮秒 1064nmNd:YAG 激光应用似乎在改善韩国人皮肤的各种光老化相关面部色素沉着方面是安全且有效的。
