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不同含 品种的局部制剂治疗银屑病的体外和人体初步研究。

In Vitro and Human Pilot Studies of Different Topical Formulations Containing Species for the Treatment of Psoriasis.

机构信息

Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, H-410028 Oradea, Romania.

Doctoral School of Biomedical Sciences, University of Oradea, H-410073 Oradea, Romania.

出版信息

Molecules. 2022 Aug 26;27(17):5499. doi: 10.3390/molecules27175499.

DOI:10.3390/molecules27175499
PMID:36080266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9458126/
Abstract

The aim of this study was to evaluate the phytochemical profile and antioxidant properties of the extracts from three species (, , ), to develop and investigate topical formulations with lyophilized forms of extracts for the treatment of psoriasis. Phytochemical screening and in vitro total antioxidant capacity (DPPH, FRAP, CUPRAC, SOD) of studied samples were examined and compared. Lyophilized extracts of roses were dissolved in Transcutol HP and different formulations of creams were prepared. Franz diffusion method was used to evaluate the drug release and biocompatibility was tested on HaCaT cells. had the best results regarding all the analyses that were conducted. After the evaluation of topical products, the formulation with extract in a self-emulsifying drug delivery system was tested on a human clinical study that involved 20 patients. At the end of the clinical study an improvement in the quality of life of the patients was observed and erythema, induration and scaling were reduced. The present study indicates that our examined extracts exhibited great phenolic content, antioxidant capacity and safety profile of topical formulation and therefore can be used as a reliable source of natural antioxidants and may be used as a complementary treatment to improve the quality life of patients with psoriasis or may be tested on another diseases.

摘要

本研究旨在评估三种玫瑰（、、）提取物的植物化学成分谱和抗氧化特性，开发并研究含有提取物的冻干形式的局部制剂，用于治疗银屑病。对研究样本进行了植物化学成分筛选和体外总抗氧化能力（DPPH、FRAP、CUPRAC、SOD）检测，并进行了比较。将玫瑰的冻干提取物溶解在 Transcutol HP 中，并制备了不同的乳膏配方。Franz 扩散法用于评估药物释放，在 HaCaT 细胞上测试生物相容性。在进行的所有分析中，表现出最好的结果。在对局部产品进行评估后，在一项涉及 20 名患者的人体临床研究中测试了含有提取物的自乳化药物传递系统的制剂。在临床研究结束时，观察到患者的生活质量得到改善，红斑、硬结和鳞屑减少。本研究表明，我们研究的提取物具有较高的酚类含量、抗氧化能力和局部制剂的安全性特征，因此可作为天然抗氧化剂的可靠来源，并可作为改善银屑病患者生活质量的辅助治疗方法，也可在其他疾病上进行测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f238/9458126/c0ed67c2e0fa/molecules-27-05499-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f238/9458126/0b51a716bc09/molecules-27-05499-g005.jpg
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