Bahramikia Seifollah, Habibi Shokofeh, Shirzadi Nasrin
Department of Biology, Lorestan University, Khorramabad, Iran.
Nat Prod Res. 2024 Sep 5:1-5. doi: 10.1080/14786419.2024.2400232.
This study aimed to investigate the antioxidant, anti-inflammatory, antifungal, and antibacterial properties of skin and Flesh methanol extract and essential oil of two varieties of species of L in Iran (northern and southern oranges). This study evaluated total phenol and flavonoid contents and the antioxidant activity of methanol extracts at different concentrations (25, 50, 100, 200, and 400 μg/ml). Albumin denaturation inhibition and RBC membrane immobilisation assays were used as an model to investigate the anti-inflammatory effects. Based on the results, the highest phenol and flavonoid contents and antioxidant activity were related to the northern orange skin. This extract also had the most significant impact on albumin denaturation inhibition and RBC membrane immobilisation by IC of 365 ± 12 µg/ml and 940 ± 22 µg/ml, respectively. In antimicrobial assays, only the skin and flesh of northern orange positively affected Gram-positive bacteria.
本研究旨在调查伊朗两种橙子品种（北部橙子和南部橙子）的果皮和果肉甲醇提取物及精油的抗氧化、抗炎、抗真菌和抗菌特性。本研究评估了不同浓度（25、50、100、200和400μg/ml）甲醇提取物的总酚和黄酮含量以及抗氧化活性。采用白蛋白变性抑制和红细胞膜固定化试验作为模型来研究其抗炎作用。基于研究结果，酚和黄酮含量最高以及抗氧化活性最强均与北部橙子的果皮相关。该提取物对白蛋白变性抑制和红细胞膜固定化也有最显著影响，其IC50分别为365±12μg/ml和940±22μg/ml。在抗菌试验中，只有北部橙子的果皮和果肉对革兰氏阳性菌有积极影响。
