Crowley T J, Macdonald M J, Zerbe G
Psychopharmacology (Berl). 1985;85(3):353-60. doi: 10.1007/BF00428201.
Monkeys receiving acetylmethadol thrice weekly were more active on dosing days, and less active on between-dose days, than while drug-free. Aggressive social behaviours increased significantly on drug-dosing days, while quiescent resting behaviors were much more common on between-dose days. Tolerance to these effects was modest, and the effects were not blocked by naltrexone. These subtle but potentially disruptive behavioral effects appear to parallel many of the actions of acetylmethadol in man.
与未用药时相比，每周接受三次醋美沙朵治疗的猴子在给药日更活跃，在两次给药间隔日则活跃度较低。在给药日，攻击性社交行为显著增加，而在两次给药间隔日，安静的休息行为更为常见。对这些效应的耐受性适中，且这些效应未被纳曲酮阻断。这些细微但可能具有干扰性的行为效应似乎与醋美沙朵在人体内的许多作用相似。
