人高密度脂蛋白相关淀粉样蛋白A。大鼠的结构特征、与载脂蛋白A-I和A-II浓度的关系以及血浆清除动力学。
Human high-density lipoprotein associated amyloid A protein. Structural characteristics, relation to apo A-I and A-II concentrations, and plasma clearance kinetics in the rat.
作者信息
Ehnholm C, Teppo A M, Ohisalo J J, Maury C P
出版信息
Scand J Rheumatol. 1985;14(2):201-8. doi: 10.3109/03009748509165505.
Five amyloid related low-molecular-weight apoproteins were isolated and characterized from the plasma high-density lipoprotein fraction of a patient with glomerulonephritis caused by basement membrane antibodies. Amino acid and carbohydrate analyses of apoSAA subfractions showed that they were non-glycosylated polypeptides rich in aspartic acid, glycine, glutamic acid, glutamine, and arginine. The apo SAA subtype pattern was similar to that described in some other pathological conditions. Following injections of the isolated SAA-rich high density lipoprotein fraction into rat circulation, similar disappearance curves were obtained for apoSAA and apo A-I.
从一名由基底膜抗体引起的肾小球肾炎患者的血浆高密度脂蛋白组分中分离并鉴定出了五种与淀粉样蛋白相关的低分子量载脂蛋白。对载脂蛋白SAA亚组分的氨基酸和碳水化合物分析表明，它们是富含天冬氨酸、甘氨酸、谷氨酸、谷氨酰胺和精氨酸的非糖基化多肽。载脂蛋白SAA亚型模式与其他一些病理状况中所描述的相似。将分离出的富含SAA的高密度脂蛋白组分注入大鼠循环后，载脂蛋白SAA和载脂蛋白A-I呈现出相似的消失曲线。
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