Benditt E P, Hoffman J S, Eriksen N, Parmelee D C, Walsh K A
Ann N Y Acad Sci. 1982;389:183-9. doi: 10.1111/j.1749-6632.1982.tb22136.x.
The putative precursor of amyloid protein AA appears in serum as an apoprotein (apoSAA) of heavier HDL fractions of lipoproteins found in humans and mice. ApoSAA is found by precipitation with specific anti-AA antibodies to be on a particle that also carries apoA-I and some C-apoproteins. In endotoxin-treated mice a lipoprotein fraction with about 2 moles of apoSAA to 1 mole of apoA-I can be isolated, an apoSAA-carrying subset of HDL being thus suggested. In mice, rapid clearance from plasma of native apoSAA compared to apoA-I suggests a special function for apoSAA. The C-terminal amino acid portion of apoSAA may play a role in this function.
淀粉样蛋白AA的假定前体以载脂蛋白（apoSAA）的形式出现在血清中，该载脂蛋白存在于人和小鼠脂蛋白的较重高密度脂蛋白（HDL）组分中。通过用特异性抗AA抗体沉淀发现，apoSAA存在于一个还携带apoA-I和一些C载脂蛋白的颗粒上。在内毒素处理的小鼠中，可以分离出一种脂蛋白组分，其中apoSAA与apoA-I的摩尔比约为2:1，由此提示存在一个携带apoSAA的HDL亚群。在小鼠中，与apoA-I相比，天然apoSAA从血浆中的快速清除表明apoSAA具有特殊功能。apoSAA的C末端氨基酸部分可能在该功能中起作用。
