Department of Chemistry, Odisha University of Technology and Research, Bhubaneswar, 751029, Odisha, India.
Department of Chemistry, Ravenshaw University, Cuttack, 753003, Odisha, India.
Carbohydr Res. 2024 Nov;545:109257. doi: 10.1016/j.carres.2024.109257. Epub 2024 Sep 3.
In recent years nanotechnologies have been applied to human health with promising results, especially in the field of drug delivery. Polymeric nanoparticles (NPs) have garnered much importance in controlled drug delivery owing to their size. Chitosan (Cs) is a well-recognized biopolymer and Cs NPs have been widely explored in drug delivery. Nonetheless, reports pertaining to green synthesis of Cs NPs are scarce. Thus, in this study, green synthesis of Cs NPs was accomplished from raw mango peel extract. Spherical Cs NPs with positively charged surface of 33.4 mV was accomplished by this process. Cs NPs, in varied content, were integrated in a guar gum network matrix resulting in a nanocomposite hydrogel. The mechanical and thermal stability of the hydrogel improved upon addition of Cs NPs. The hydrogel exhibited smart swelling, good antioxidant and anti-inflammatory propensities. Cs NPs encapsulating 5-Fluorouracil demonstrated a controlled release drug profile in the colorectum and the kinetics implied the anomalous nature of drug release mechanism. The exposure of the drug-loaded nanocomposite hydrogel displayed improved anticancer effects in HT-29 colon cancer cells. Taken altogether, this study puts forth the greater efficacy of Cs NPs in controlled drug delivery for anticancer therapy.
近年来，纳米技术在人类健康领域得到了广泛应用，并取得了令人瞩目的成果，尤其是在药物输送领域。由于聚合物纳米粒子（NPs）的尺寸较小，因此在控制药物输送方面受到了广泛关注。壳聚糖（Cs）是一种公认的生物聚合物，其纳米粒子已被广泛应用于药物输送。然而，关于 Cs NPs 绿色合成的报道却很少。因此，在本研究中，我们从芒果皮提取物中成功地进行了 Cs NPs 的绿色合成。通过该过程，获得了表面带正电荷、粒径为 33.4 mV 的球形 Cs NPs。将不同含量的 Cs NPs 整合到瓜尔胶网络基质中，得到了纳米复合水凝胶。Cs NPs 的加入提高了水凝胶的机械和热稳定性。该水凝胶具有智能溶胀、良好的抗氧化和抗炎性能。包载 5-氟尿嘧啶的 Cs NPs 表现出在结肠中的控释药物特性，其动力学表明药物释放机制具有异常性质。载药纳米复合水凝胶的暴露显示出对 HT-29 结肠癌细胞的抗癌作用增强。总的来说，本研究表明 Cs NPs 在抗癌治疗中的控释药物方面具有更大的疗效。
