[评估化合物对脂质酶促过氧化作用的有效性]
[Assessment of the effectiveness of the action of chemical compounds on the enzymatic peroxidation of lipids].
作者信息
Komarov P G, Bilenko M V, Shvedova A A, Kagan V E
出版信息
Vopr Med Khim. 1985 Mar-Apr;31(2):40-5.
Inhibitory effects of 3-hydroxypyridines and of some drugs on NADPH-dependent lipid peroxidation was studied in liver microsomes of rats using a spectrophotometric technique with continuous monitoring of accumulation of peroxidation products. At the same time, inhibition of fatty acyl peroxidation catalyzed by the NADPH-dependent system and lipoxygenase from soybean was studied. The data obtained suggest that peroxidation, catalyzed by enzymes of two different types, may be inhibited to different degree by the same chemical compounds.
利用分光光度技术连续监测过氧化产物的积累，研究了3-羟基吡啶及某些药物对大鼠肝脏微粒体中NADPH依赖性脂质过氧化的抑制作用。同时，研究了NADPH依赖性系统和大豆脂氧合酶催化的脂肪酰基过氧化的抑制作用。所得数据表明，由两种不同类型的酶催化的过氧化作用，可能会被相同的化合物不同程度地抑制。
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