First Department of Orthopaedic Surgery, Athens University Medical School (NKUA), Athens, 12462, Greece.
Laboratory of Neuromuscular and Cardiovascular Study of Motion (LANECASM), Physiotherapy Department, University of West Attica (UNIWA), Egaleo, 12243, Greece.
Arch Orthop Trauma Surg. 2024 Sep;144(9):4171-4178. doi: 10.1007/s00402-024-05505-0. Epub 2024 Sep 6.
Hip osteoarthritis (OA) is a common joint pathology that significantly constrains functional capacity. Assessing the impact of hip OA on functionality is crucial for research and clinical practices. The study aimed to assess hip OA patients' functionality using the Timed Up and Go (TUG) test and to evaluate its diagnostic ability to differentiate between different grades of hip OA. We hypothesized that the severity of hip OA would impact the time required to complete the TUG test.
Patients (Ν = 606) with unilateral, primary hip OA were selected from de-identified data and divided according to the radiographic Kellgren-Lawrence classification system (groups: Grade 2, Grade 3, and Grade 4). Groups' differences were assessed using the X test of independence and the one-way ANOVA model. Correlations between dependent and independent variables were assessed using Pearson's correlation coefficient (r). A receiver operating characteristic (ROC) analysis was conducted to assess the TUG test's ability to differentiate between the hip OA grades.
Statistically significant differences were found among the three groups in age, gender distribution, TUG test, and occasional cane use (all p-values < 0.001). The correlation analysis shows a significant and strong positive correlation between TUG performance time and hip OA grades (r = .78, p < .001). The adjusted odds ratios (OR) were: Grade2-3=(2.29[95%CI: 1.89, 2.77], p < .001) and Grade3-4=(1.47[95%CI: 1.34, 1.62], p < .001). The TUG cut-off points from the ROC analysis were: Grades 2-3 = 10.25 s, Grades 2-4 = 11.35 s, and Grades 3-4 = 12.8 s.
This study provides evidence that the duration of the TUG test significantly increased with the severity of the disease. TUG can offer real-time data on the management and progression of hip OA. Future studies should explore the correlation between hip OA and the TUG test, as understanding the relationship can influence treatment and patient outcomes.
髋关节骨关节炎(OA)是一种常见的关节病变,严重限制了功能能力。评估髋关节 OA 对功能的影响对于研究和临床实践至关重要。本研究旨在使用计时起立行走测试(TUG)评估髋关节 OA 患者的功能,并评估其区分不同严重程度髋关节 OA 的诊断能力。我们假设髋关节 OA 的严重程度会影响完成 TUG 测试所需的时间。
从去识别数据中选择单侧、原发性髋关节 OA 患者(N = 606),并根据 X 射线 Kellgren-Lawrence 分类系统(组:2 级、3 级和 4 级)进行分组。使用独立性 X 检验和单向方差分析模型评估组间差异。使用 Pearson 相关系数(r)评估相关和独立变量之间的相关性。进行受试者工作特征(ROC)分析以评估 TUG 测试区分髋关节 OA 等级的能力。
三组之间在年龄、性别分布、TUG 测试和偶尔使用手杖方面存在统计学显著差异(所有 p 值 < 0.001)。相关性分析显示 TUG 测试时间与髋关节 OA 分级之间存在显著且强正相关(r = .78,p < .001)。调整后的优势比(OR)为:Grade2-3=(2.29[95%CI: 1.89, 2.77],p < .001) 和 Grade3-4=(1.47[95%CI: 1.34, 1.62],p < .001)。ROC 分析得出的 TUG 截断点为:Grades 2-3 = 10.25 秒,Grades 2-4 = 11.35 秒,Grades 3-4 = 12.8 秒。
本研究表明 TUG 测试的持续时间随着疾病严重程度的增加而显著增加。TUG 可以提供有关髋关节 OA 管理和进展的实时数据。未来的研究应探讨髋关节 OA 与 TUG 测试之间的相关性,因为了解这种关系可以影响治疗和患者的结局。