Institute of Pharmacy and Pharmacology, College of Basic Medical Science, Hengyang Medical School, University of South China, Hengyang, China.
Traffic. 2024 Sep;25(9):e12951. doi: 10.1111/tra.12951.
Mitochondria, the dynamic organelles responsible for energy production and cellular metabolism, have the metabolic function of extracting energy from nutrients and synthesizing crucial metabolites. Nevertheless, recent research unveils that intercellular mitochondrial transfer by tunneling nanotubes, tumor microtubes, gap junction intercellular communication, extracellular vesicles, endocytosis and cell fusion may regulate mitochondrial function within recipient cells, potentially contributing to disease treatment, such as nonalcoholic steatohepatitis, glioblastoma, ischemic stroke, bladder cancer and neurodegenerative diseases. This review introduces the principal approaches to intercellular mitochondrial transfer and examines its role in various diseases. Furthermore, we provide a comprehensive overview of the inhibitors and activators of intercellular mitochondrial transfer, offering a unique perspective to illustrate the relationship between intercellular mitochondrial transfer and diseases.
线粒体是负责能量生产和细胞代谢的动态细胞器，具有从营养物质中提取能量和合成关键代谢物的代谢功能。然而，最近的研究揭示了通过隧道纳米管、肿瘤微管、间隙连接细胞间通讯、细胞外囊泡、内吞作用和细胞融合进行细胞间线粒体转移，可以调节受体细胞内的线粒体功能，可能有助于治疗非酒精性脂肪性肝炎、神经胶质瘤、缺血性中风、膀胱癌和神经退行性疾病等疾病。本综述介绍了细胞间线粒体转移的主要方法，并探讨了其在各种疾病中的作用。此外，我们还全面概述了细胞间线粒体转移的抑制剂和激活剂，提供了一个独特的视角来阐明细胞间线粒体转移与疾病之间的关系。
