Khosravani Hengameh, Ataee Disfani Reza, Farhadi Bahar, Tohidian Mobina, Garrosi Lida, Shirvani Proushat, Zabihi Mohammad Reza, Akhoondian Mohammad, Norouzkhani Narges, Farzan Ramyar
Medicine Group, Amin Entezami University, Tehran, Iran.
Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Ann Med Surg (Lond). 2024 Jun 24;86(9):5170-5178. doi: 10.1097/MS9.0000000000002317. eCollection 2024 Sep.
Esophageal chemical burns often occur through accidental or intentional oral consumption of chemical agents and lead to severe complications such as esophageal stricture, acute perforation, and even death. Esophageal squamous cell carcinoma is a squamous epithelium tumor that lines the normal esophagus. Additionally, adenocarcinomas are tumors located at the interface between the distal esophagus and the proximal gastric and divided into esophageal adenocarcinoma and gastric-cardia adenocarcinoma. Various conditions, such as chemical burns, are considered risk factors in the disease's pathogenesis. In the in-silico study, the authors aim to present the relationship between chemical burns and esophageal cancer by analyzing bioinformatics genetic data.
The proper gene set was extracted using the 'GEO' database. The string web tool was utilized to form the gene-interaction network. Gephi and Cytoscape software were applied to achieve network analysis.
According to in-silico data, 26 genes, including NCAPH, DLGAP5, CCNB1, KIF11, KIAA0101, CDCA5, BIRC5, NUF2, BUB1B, RRM2, TTK, CDC20, NUSAP1, CCNB2, CCNA2, MELK, TPX2, PRC1, KIF4A, CENPF, TOP2A, CDK1, ASPM, CEP55, BUB1, KIF20A were extracted that can be regarded as the most critical shared genes between chemical burns and esophageal cancer.
In sum, esophageal chemical burns can be related to the occurrence of esophageal cancer. Moreover, esophageal chemical burn is an external factor that upregulates present genes and can be regarded as a worsening prognosis or risk factor for esophageal cancer.
食管化学性烧伤常因意外或故意经口摄入化学制剂而发生，并导致严重并发症，如食管狭窄、急性穿孔，甚至死亡。食管鳞状细胞癌是一种发生于正常食管内衬鳞状上皮的肿瘤。此外，腺癌是位于食管远端与胃近端交界处的肿瘤，分为食管腺癌和贲门腺癌。多种情况，如化学性烧伤，被认为是该疾病发病机制中的危险因素。在这项计算机模拟研究中，作者旨在通过分析生物信息学基因数据来呈现化学性烧伤与食管癌之间的关系。
使用“GEO”数据库提取合适的基因集。利用String网络工具构建基因相互作用网络。应用Gephi和Cytoscape软件进行网络分析。
根据计算机模拟数据，提取出26个基因，包括NCAPH、DLGAP5、CCNB1、KIF11、KIAA0101、CDCA5、BIRC5、NUF2、BUB1B、RRM2、TTK、CDC20、NUSAP1、CCNB2、CCNA2、MELK、TPX2、PRC1、KIF4A、CENPF、TOP2A、CDK1、ASPM、CEP55、BUB1、KIF20A，这些基因可被视为化学性烧伤和食管癌之间最关键的共享基因。
总之，食管化学性烧伤可能与食管癌的发生有关。此外，食管化学性烧伤是一种上调现有基因的外部因素，可被视为食管癌预后恶化或危险因素。
