Wang Miaomiao, Shen Qiuyu, Pang Jianyu, Mao Yu, Li Xiaofei, Tao Yanxia, Tang Wenru, Sun Ruifen, Zhou Xuhong
Office of Science and Technology, Yunnan University of Chinese Medicine, Kunming, Yunnan, China.
Department of Pharmacy, Bozhou Hospital of Traditional Chinese Medicine, Bozhou, Anhui, China.
Front Plant Sci. 2024 Aug 22;15:1438967. doi: 10.3389/fpls.2024.1438967. eCollection 2024.
is a plant that holds high value in terms of its edibility, medicinal properties, and ornamental appeal. Creating no sense he aim of this study was to evaluate the antioxidant and antitumor properties of extracts derived from various parts of the carnation plant. Metabolomics technology was employed to identify the primary chemical constituents.
Initially, we measured the total phenolic and total flavonoid contents in carnation roots, stems, leaves, and flowers, followed by assessing the antioxidant and anti-tumor capabilities of each component using diverse experimental methods. Subsequently, UPLC-MS/MS was employed to identify metabolites in different parts of carnation and investigate their roles in antioxidant and anti-tumor activities.
Mention numerical value- for better underatnding- Results of the study indicated that the methanol extract obtained from carnation flowers and roots exhibited superior antioxidant capacity compared to that from the stems and leaves. This disparity may be attributed to the abundance of polyphenols, flavonoids, and antioxidants present in the flowers, including methyl ferulate and luteolin-4'-O-glucoside. Furthermore, the significant presence of the anthraquinone compound rhein-8-O-glucoside in carnation roots may contribute to their enhanced antioxidant properties. Ten distinct compounds were isolated and recognized in carnation flowers, with Isoorientin 2"-O-rhamnoside and Kurarinone demonstrating notable antioxidant activity and binding affinity to SOD1 and SOD3, as validated through antioxidant screening and molecular docking.
Overall, the findings from this study have expanded our knowledge of the phytochemical composition across different anatomical regions of the carnation plant, providing valuable insights for its holistic utilization.
康乃馨是一种在可食用性、药用特性和观赏价值方面具有很高价值的植物。本研究旨在评估康乃馨植物各部位提取物的抗氧化和抗肿瘤特性,尽管这毫无意义。采用代谢组学技术鉴定主要化学成分。
首先,我们测定了康乃馨根、茎、叶和花中的总酚和总黄酮含量,然后使用多种实验方法评估各成分的抗氧化和抗肿瘤能力。随后,采用超高效液相色谱-串联质谱法(UPLC-MS/MS)鉴定康乃馨不同部位的代谢物,并研究它们在抗氧化和抗肿瘤活性中的作用。
提及数值以便更好理解。研究结果表明,与茎和叶相比,从康乃馨花和根中获得的甲醇提取物表现出更高的抗氧化能力。这种差异可能归因于花中丰富的多酚、黄酮类化合物和抗氧化剂,包括阿魏酸甲酯和木犀草素-4'-O-葡萄糖苷。此外,康乃馨根中大量存在的蒽醌化合物大黄素-8-O-葡萄糖苷可能有助于其增强抗氧化性能。在康乃馨花中分离并鉴定出10种不同的化合物,通过抗氧化筛选和分子对接验证,异荭草素2''-O-鼠李糖苷和苦参酮表现出显著的抗氧化活性以及与超氧化物歧化酶1(SOD1)和超氧化物歧化酶3(SOD3)的结合亲和力。
总体而言,本研究的结果扩展了我们对康乃馨植物不同解剖区域植物化学成分的认识,为其全面利用提供了有价值的见解。