淋病奈瑟菌对2-乙酰吡啶硫代氨基脲的体外敏感性
In vitro susceptibility of Neisseria gonorrhoeae to 2-acetylpyridine thiosemicarbazones.
作者信息
Christenson B, Rodríguez J R, Gorbea H F, Ramírez-Rond C H
出版信息
Antimicrob Agents Chemother. 1985 Apr;27(4):570-3. doi: 10.1128/AAC.27.4.570.
Abstract
MICs of 20 2-acetylpyridine thiosemicarbazones and penicillin were determined for 25 clinical isolates of beta-lactamase-positive and beta-lactamase-negative Neisseria gonorrhoeae strains. The compounds most active against the beta-lactamase-producing strains were the N4,N4-disubstituted derivatives and the thiosemicarbazone derivatives of the 2-acetylpyridines, followed by the other compounds related to the 2-acetylpyridine thiosemicarbazones.
摘要
对25株β-内酰胺酶阳性和β-内酰胺酶阴性淋病奈瑟菌临床分离株测定了20种2-乙酰吡啶硫代卡巴腙和青霉素的最低抑菌浓度（MIC）。对产β-内酰胺酶菌株活性最强的化合物是N4,N4-二取代衍生物和2-乙酰吡啶的硫代卡巴腙衍生物，其次是与2-乙酰吡啶硫代卡巴腙相关的其他化合物。
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