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利多卡因和布比卡因用于诊断性内侧支阻滞时患者感知的作用持续时间:一项多中心研究。

Patient-perceived duration of effect of lidocaine and bupivacaine following diagnostic medial branch blocks; a multicenter study.

作者信息

Schneider Byron J, Joshi Mihir, Ehsanian Reza, McCormick Zachary L, Patel Jaymin, Zheng Patricia, Nagpal Ameet S

机构信息

Department of Physical Medicine & Rehabilitation, Vanderbilt University School of Medicine, USA.

Department of Anesthesiology, UT Health San Antonio Long School of Medicine, USA.

出版信息

Interv Pain Med. 2022 Mar 18;1(2):100083. doi: 10.1016/j.inpm.2022.100083. eCollection 2022 Jun.

Abstract

OBJECTIVE

To quantify the duration of pain relief reported in association with lidocaine and bupivacaine in patients suffering from axial back pain, who reported a response of ≥80% relief lasting at least 30 ​min following medial branch blocks(MBB).

DESIGN

A retrospective review.

METHODS

Setting & Subjects: Four academic medical centers utilized a uniform pain diary. It was administered to consecutive patients after undergoing MBB. This pain diary included NRS pain score and percentage of pain relief (PPR) at 12 designated time points.

RESULTS

One hundred and fifty pain diaries were collected and analyzed. 42 blocks were performed in the cervical spine, 7 in the thoracic spine, and 101 in the lumbar spine. By NRS, 32% of pain diaries indicated that the patient experienced ≥80% pain relief at the 30-min and 42.7% (64/150) did so by PPR. Mean duration of ≥80% pain relief as measured by NRS in the bupivacaine subgroup was 3.5 ​h (SD 8.7, 95% CI 0.6-6.5) versus mean duration of 16.4 ​h (SD 19.6, 95% CI 5.4-27.4) in the lidocaine subgroup. Mean duration of ≥80% pain relief as measured by PPR in the bupivacaine subgroup was 19.2 ​h (SD 19.2, 95% CI 13.3-25.1) versus mean duration of 12.2 ​h (SD 15.9, 95% CI 5.6-18.8) in the lidocaine subgroup.

CONCLUSIONS

This study demonstrates that there is no discernable or statistically significant difference in the duration of effect when comparing lidocaine to bupivacaine in patients that experience 80% or more relief following a medial branch block. This data suggests any emphasis on concordant duration of relief from specific anesthetics utilized for diagnostic medial branch blocks should be reconsidered.

摘要

目的

量化患有轴性背痛的患者在接受内侧支阻滞(MBB)后报告疼痛缓解≥80%且持续至少30分钟时,利多卡因和布比卡因相关的疼痛缓解持续时间。

设计

一项回顾性研究。

方法

设置与受试者:四个学术医疗中心使用统一的疼痛日记。在患者接受MBB后连续发放。该疼痛日记包括12个指定时间点的数字评分量表(NRS)疼痛评分和疼痛缓解百分比(PPR)。

结果

收集并分析了150份疼痛日记。颈椎进行了42次阻滞,胸椎7次,腰椎101次。根据NRS,32%的疼痛日记表明患者在30分钟时疼痛缓解≥80%,根据PPR则为42.7%(64/150)。布比卡因亚组中,按NRS测量的≥80%疼痛缓解的平均持续时间为3.5小时(标准差8.7,95%置信区间0.6 - 6.5),而利多卡因亚组为16.4小时(标准差19.6,95%置信区间5.4 - 27.4)。布比卡因亚组中,按PPR测量的≥80%疼痛缓解的平均持续时间为19.2小时(标准差19.2,95%置信区间13.3 - 25.1),而利多卡因亚组为12.2小时(标准差15.9,95%置信区间5.6 - 18.8)。

结论

本研究表明,在接受内侧支阻滞后疼痛缓解80%或更多的患者中,比较利多卡因和布比卡因时,在作用持续时间上没有明显的或统计学上的显著差异。该数据表明,对于诊断性内侧支阻滞使用的特定麻醉剂,任何对一致的缓解持续时间的强调都应重新考虑。

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