Tokuc Ecem Onder, Seyyar Sevim Ayca, Basaran Ece, Ozdemir Sumeyra Nur, Karabas Levent
Department of Ophthalmology, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye.
Department of Ophthalmology, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye.
Beyoglu Eye J. 2024 Sep 1;9(3):149-154. doi: 10.14744/bej.2024.92489. eCollection 2024.
Iron is recognized as a significant contributor to oxidative damage, and its levels tend to rise with age, potentially worsening age-related diseases. The aim of this study was to investigate the role of serum iron metabolism markers in the pathogenesis of age-related macular degeneration (AMD).
The files of all AMD patients in Kocaeli University School of Medicine between January 2017 and March 2020 were reviewed retrospectively. By examining the files of AMD patients who applied to the eye outpatient clinic on the same dates, those dry AMD (dAMD) and neovascular AMD (nAMD) were recorded. As a control group, the records of patients without any AMD findings were obtained from the files of all patients who visited the clinic during the same time period. All records were recorded for analysis, including a comprehensive ophthalmological examination, laboratory data of fasting blood tests, and an internal medicine outpatient examination.
Of the 164 participants, 50 were dAMD patients, 51 were nAMD patients, and 63 were patients non-AMD (control group). There was a significant difference between the groups' mean corpuscular volume (MCV), serum ferritin, and total iron-binding capacity (TIBC) (p<0.050). It was observed that the ferritin of those with AMD was significantly higher than the control group, whereas MCV and TIBC were found to be significantly lower (p<0.050). There was no significant difference in serum iron marker levels between nAMD and dAMD patients (p>0.05).
Assessing serum iron status indicators during the routine monitoring of AMD may provide insights into the associated risk profile of the condition.
铁被认为是氧化损伤的重要促成因素，其水平往往随年龄增长而升高，可能会使与年龄相关的疾病恶化。本研究的目的是探讨血清铁代谢标志物在年龄相关性黄斑变性（AMD）发病机制中的作用。
回顾性分析了2017年1月至2020年3月间科贾埃利大学医学院所有AMD患者的病历。通过检查在同一日期到眼科门诊就诊的AMD患者病历，记录干性AMD（dAMD）和新生血管性AMD（nAMD）患者。作为对照组，从同一时期到门诊就诊的所有患者病历中获取无任何AMD表现患者的记录。记录所有分析数据，包括全面的眼科检查、空腹血液检查的实验室数据以及内科门诊检查结果。
164名参与者中，50名为dAMD患者，51名为nAMD患者，63名为非AMD患者（对照组）。各组的平均红细胞体积（MCV）、血清铁蛋白和总铁结合力（TIBC）存在显著差异（p<0.050）。观察到AMD患者的铁蛋白显著高于对照组，而MCV和TIBC显著低于对照组（p<0.050）。nAMD和dAMD患者之间的血清铁标志物水平无显著差异（p>0.05）。
在AMD的常规监测过程中评估血清铁状态指标可能有助于了解该疾病的相关风险情况。
