School of Basic Medicine, Qingdao Medical College, Qingdao, University, Qingdao 266071, China.
Department of Obstetrics and Gynecology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, 266000, China.
Food Funct. 2024 Sep 30;15(19):9632-9661. doi: 10.1039/d4fo02802c.
Metabolic syndrome (MetS) is a disease condition incorporating the abnormal accumulation of various metabolic components, including overweight or abdominal obesity, insulin resistance and abnormal glucose tolerance, hypertension, atherosclerosis, or dyslipidemia. It has been proved that the gut microbiota and microbial-derived products play an important role in regulating lipid metabolism and thus the onset and development of MetS. Previous studies have demonstrated that oligosaccharides with prebiotic effects, such as chitosan oligosaccharides, can regulate the structure of the microbial community and its derived products to control weight and reduce MetS associated with obesity. Alginate oligosaccharides (AOS), natural products extracted from degraded alginate salts with high solubility and extensive biological activity, have also been found to modulate gut microbiota. This review aims to summarize experimental evidence on the positive effects of AOS on different types of MetS while providing insights into mechanisms through which AOS regulates gut microbiota for preventing and treating MetS.
代谢综合征（MetS）是一种疾病状态，包括各种代谢成分的异常积累，包括超重或腹部肥胖、胰岛素抵抗和葡萄糖耐量异常、高血压、动脉粥样硬化或血脂异常。已经证明，肠道微生物群及其衍生产物在调节脂质代谢以及因此代谢综合征的发生和发展方面发挥着重要作用。先前的研究表明，具有益生元作用的低聚糖，如壳寡糖，可以调节微生物群落的结构及其衍生产物，以控制体重和减轻与肥胖相关的代谢综合征。藻酸盐寡糖（AOS）是从高溶解度和广泛生物活性的降解藻酸盐盐中提取的天然产物，也被发现可以调节肠道微生物群。本综述旨在总结 AOS 对不同类型代谢综合征的积极影响的实验证据，同时深入了解 AOS 调节肠道微生物群以预防和治疗代谢综合征的机制。
