坐位八段锦锻炼对接受无创通气的脓毒症患者早期康复的影响：一项随机对照试验。
Effect of Sitting Baduanjin exercise on early rehabilitation of sepsis patients with non-invasive ventilation : a randomized controlled trial.
机构信息
Intensive Care Unit, The Second Clinical College of Guangzhou University of Chinese Medicine, No 111 Dade Road, Guangzhou, 510120, China.
出版信息
BMC Complement Med Ther. 2024 Sep 6;24(1):330. doi: 10.1186/s12906-024-04626-8.
BACKGROUND
For patients with sepsis receiving non-invasive ventilation (NIV), early rehabilitation is crucial. The Sitting Baduanjin (SBE) is an efficient early rehabilitation exercise suitable for bed patients. There is no consensus about the effect of SBE on the early rehabilitation of septic patients with NIV. This study focused on how the SBE affected the early rehabilitation of sepsis patients with NIV.
METHODS
96 sepsis patients with NIV were randomly assigned to either an Baduanjin group that received the SBE based on the routine rehabilitation exercise (n = 48) or a control group (n = 48) that received routine rehabilitation exercise. The primary outcome was the Medical Research Council(MRC)score, and the Barthel Index score, the duration of NIV, length of ICU stay, length of total stay, hospitalization expense as secondary outcomes.
RESULTS
A total of 245 sepsis patients were screened, with 96 randomly assigned. The study was completed by 90 patients out of the 96 participants.Results revealed that the MRC score increased in both groups, but the improvement of muscle strength in Baduanjin group was more obvious, with statistical significance (p < 0.001).There was statistically significantly difference between the two groups in Barthel Index at the day of transfer out of ICU(P = 0.028).The patients in the Baduanjin group had an average reduction of 24.09 h in the duration of NIV and 3.35 days in total length of hospital stay compared with the control group (p < 0.05).Of note, the Baduanjin group had significantly reduction the total hospitalization expense. No serious adverse events occurred during the intervention period.
CONCLUSIONS
In patients with sepsis, the SBE appears to improve muscle strength and activities of daily living (ADL), and lowed the duration of NIV, the length of the total stay, and the hospitalization expense.
TRIAL REGISTRATION
The study registered on the Chinese Clinical Trial Registry ( www.chictr.org.cn ), Clinical Trials identifier ChiCTR1800015011 (28/02/2018).
背景
对于接受无创通气（NIV）的脓毒症患者，早期康复至关重要。坐式八段锦（SBE）是一种适合卧床患者的高效早期康复运动。目前，对于 SBE 对接受 NIV 的脓毒症患者早期康复的影响尚未达成共识。本研究重点探讨 SBE 如何影响接受 NIV 的脓毒症患者的早期康复。
方法
96 例接受 NIV 的脓毒症患者被随机分为接受常规康复运动基础上的 SBE 组（n=48）或对照组（n=48）。主要结局为改良医学研究委员会（MRC）评分和巴氏指数评分，次要结局为 NIV 持续时间、ICU 住院时间、总住院时间、住院费用。
结果
共筛选出 245 例脓毒症患者，96 例患者被随机分配。96 名参与者中，90 名完成了研究。结果显示，两组 MRC 评分均增加，但 SBE 组的肌力改善更明显，差异有统计学意义（p<0.001）。两组患者在转出 ICU 当日的巴氏指数评分差异有统计学意义（P=0.028）。与对照组相比，SBE 组患者的 NIV 持续时间平均减少 24.09 小时，总住院时间缩短 3.35 天（p<0.05）。值得注意的是，SBE 组的总住院费用明显降低。干预期间未发生严重不良事件。
结论
对于脓毒症患者，SBE 似乎可以改善肌力和日常生活活动能力（ADL），降低 NIV 持续时间、总住院时间和住院费用。
试验注册
本研究在中国临床试验注册中心（www.chictr.org.cn）注册，注册号 ChiCTR1800015011（28/02/2018）。
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