Mostafavi Mehrnaz, Dehbashi Elham, Rahmani Khajeh Faraz, Nouri Masoumeh, Kadkhodaei Eliaderani Mahdis, Aghajamal Avval Nahal, Ghasemi Moein, Seyedi Dina, Sharafi Malihe, Morovatshoar Reza, Javankiani Sepide, Azani Alireza, Sadri Farzad, Behfar Qumars
Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Faculty of Pharmacy, Zanjan University of Medical Science, Zanjan, Iran.
Med Oncol. 2025 Jul 21;42(8):357. doi: 10.1007/s12032-025-02934-8.
Colorectal cancer (CRC) continues to represent a significant global health challenge due to its high incidence and mortality rates. Among the signaling pathways implicated in CRC, the Hippo pathway has gained considerable attention for its evolutionarily conserved role in regulating cellular proliferation, programmed cell death, and organ size control. The recent studies have revealed that alterations in this pathway contribute not only to tumor initiation but also to metastasis and therapy resistance. Emerging evidence underscores the pivotal involvement of noncoding RNAs (ncRNAs)-including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs)-in modulating this pathway, particularly through the regulation of its core effectors, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ). The intricate crosstalk between ncRNAs and Hippo signaling components suggests a multilayered regulatory mechanism that warrants further investigation. This review provides mechanistic insights into the dynamic crosstalk between ncRNAs and the YAP/TAZ axis, highlighting their roles in tumor progression, metastasis, and chemoresistance. Considering these intricate interactions, this review further emphasizes the emerging therapeutic and biomarker potential of ncRNAs, offering novel perspectives for both targeted intervention and early diagnosis in CRC management.
由于结直肠癌（CRC）的高发病率和死亡率，它仍然是一项重大的全球健康挑战。在与CRC相关的信号通路中，Hippo通路因其在调节细胞增殖、程序性细胞死亡和器官大小控制方面具有进化保守作用而备受关注。最近的研究表明，该通路的改变不仅有助于肿瘤的起始，还与转移和治疗耐药性有关。新出现的证据强调了非编码RNA（ncRNA）——包括微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）——在调节该通路中的关键作用，特别是通过调节其核心效应因子Yes相关蛋白（YAP）和含PDZ结合基序的转录共激活因子（TAZ）。ncRNA与Hippo信号成分之间复杂的相互作用表明存在一种多层调节机制，值得进一步研究。本综述提供了关于ncRNA与YAP/TAZ轴之间动态相互作用的机制见解，强调了它们在肿瘤进展、转移和化疗耐药性中的作用。考虑到这些复杂的相互作用，本综述进一步强调了ncRNA新出现的治疗和生物标志物潜力，为CRC管理中的靶向干预和早期诊断提供了新的视角。
