School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China.
School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, China.
Biomaterials. 2025 Feb;313:122810. doi: 10.1016/j.biomaterials.2024.122810. Epub 2024 Sep 3.
The development of biosensing electronics for real-time sweat analysis has attracted increasing research interest due to their promising applications for non-invasive health monitoring. However, one of the critical challenges lies in the sebum interference that largely limits the sensing reliability in practical scenarios. Herein, we report a flexible epidermal secretion-purified biosensing patch with a hydrogel filtering membrane that can effectively eliminate the impact of sebum and sebum-soluble substances. The as-prepared sebum filtering membranes feature a dual-layer sebum-resistant structure based on the poly(hydroxyethyl methacrylate) hydrogel functionalized with nano-brush structured poly(sulfobetaine) to eliminate interferences and provide self-cleaning capability. Furthermore, the unidirectional flow microfluidic channels design based on the Tesla valve was incorporated into the biosensing patch to prevent external sebum contamination and allow effective sweat refreshing for reliable sensing. By seamlessly combining these components, the epidermal secretion-purified biosensing patch enables continuous monitoring of sweat uric acid, pH, and sodium ions with significantly improved accuracy of up to 12 %. The proposed strategy for enhanced sweat sensing reliability without sebum interference shows desirable compatibility for different types of biosensors and would inspire the advances of flexible and wearable devices for non-invasive healthcare.
由于在非侵入性健康监测方面具有广阔的应用前景，用于实时汗液分析的生物传感电子学的发展引起了越来越多的研究兴趣。然而，其中一个关键挑战在于皮脂干扰，这在很大程度上限制了实际场景中的传感可靠性。在此，我们报告了一种具有水凝胶过滤膜的灵活表皮分泌物纯化生物传感贴，它可以有效消除皮脂和皮脂溶性物质的影响。所制备的皮脂过滤膜具有基于纳米刷结构聚（磺酸甜菜碱）功能化的聚（羟乙基甲基丙烯酸酯）水凝胶的双层抗皮脂结构，可消除干扰并提供自清洁能力。此外，基于特斯拉阀的单向流微流道设计被整合到生物传感贴中，以防止外部皮脂污染并允许有效的汗液更新，从而实现可靠的传感。通过无缝结合这些组件，表皮分泌物纯化生物传感贴能够以高达 12%的显著改善精度来连续监测汗液尿酸、pH 值和钠离子。该方法在没有皮脂干扰的情况下增强了汗液传感的可靠性，与不同类型的生物传感器具有良好的兼容性，将为非侵入性医疗保健的柔性和可穿戴设备的发展提供灵感。
