Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
Neurosci Biobehav Rev. 2024 Nov;166:105873. doi: 10.1016/j.neubiorev.2024.105873. Epub 2024 Sep 5.
This systematic review and meta-analysis aimed to comprehensively describe whether experiencing a variety of childhood maltreatment types predicts a variety of substance use/misuse types among youth, beyond the narrow scope covered in previous systematic reviews on similar topics. A literature search was conducted in June, 2022 using PubMed, PsycInfo, and Embase. 58 studies (total participant n=170,749) were included. These studies were primarily organized by substance type outcomes including alcohol (n=43), cannabis (n=25), unspecified substances (n=25), and other specific substances (n=10). Results were further stratified by maltreatment type. For specific maltreatment and substance type combinations, the majority of studies indicated that childhood maltreatment was a significant predictor of substance use/misuse in youth. Of the 10 meta-analyses we conducted, significant associations were found for the majority (9/10) of maltreatment and substance type combinations. For instance, unspecified childhood maltreatment increased the probability of youth alcohol use by about four times, which was the highest relative risk found. In conclusion, this study shows that childhood maltreatment is a predictor of youth substance use/misuse.
本系统评价和荟萃分析旨在全面描述经历多种类型的儿童期虐待是否会预测青少年出现多种物质使用/滥用类型，超越之前关于类似主题的系统评价所涵盖的狭窄范围。2022 年 6 月，使用 PubMed、PsycInfo 和 Embase 进行了文献检索。共纳入 58 项研究（总参与者 n=170749）。这些研究主要按物质类型结局组织，包括酒精（n=43）、大麻（n=25）、未特指物质（n=25）和其他特定物质（n=10）。结果还按虐待类型进行了分层。对于特定的虐待和物质类型组合，大多数研究表明，儿童期虐待是青少年物质使用/滥用的重要预测因素。在我们进行的 10 项荟萃分析中，大多数（9/10）的虐待和物质类型组合都存在显著关联。例如，未特指的儿童期虐待使青少年饮酒的可能性增加了约四倍，这是发现的最高相对风险。总之，这项研究表明，儿童期虐待是青少年物质使用/滥用的预测因素。
