Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India.
Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India.
Int J Biol Macromol. 2024 Nov;279(Pt 3):135253. doi: 10.1016/j.ijbiomac.2024.135253. Epub 2024 Sep 5.
The rise of antimicrobial resistance has positioned ESKAPE pathogens as a serious global health threat, primarily due to the limitations and frequent failures of current treatment options. This growing risk has spurred the scientific community to seek innovative antibiotic therapies and improved oversight strategies. This review aims to provide a comprehensive overview of the origins and resistance mechanisms of ESKAPE pathogens, while also exploring next-generation treatment strategies for these infections. In addition, it will address both traditional and novel approaches to combating antibiotic resistance, offering insights into potential new therapeutic avenues. Emerging research underscores the urgency of developing new antimicrobial agents and strategies to overcome resistance, highlighting the need for novel drug classes and combination therapies. Advances in genomic technologies and a deeper understanding of microbial pathogenesis are crucial in identifying effective treatments. Integrating precision medicine and personalized approaches could enhance therapeutic efficacy. The review also emphasizes the importance of global collaboration in surveillance and stewardship, as well as policy reforms, enhanced diagnostic tools, and public awareness initiatives, to address resistance on a worldwide scale.
耐抗生素性的出现使 ESKAPE 病原体成为严重的全球健康威胁，主要是因为当前治疗方案的局限性和频繁失败。这种日益增长的风险促使科学界寻求创新的抗生素治疗方法和更好的监督策略。本综述旨在全面概述 ESKAPE 病原体的起源和耐药机制，同时探讨针对这些感染的下一代治疗策略。此外，它还将讨论对抗抗生素耐药性的传统和新型方法，为潜在的新治疗途径提供见解。新的研究强调了开发新的抗菌剂和克服耐药性的策略的紧迫性，突出了新型药物类别和联合疗法的必要性。基因组技术的进步和对微生物发病机制的更深入了解对于确定有效的治疗方法至关重要。整合精准医学和个性化方法可以提高治疗效果。该综述还强调了在全球范围内进行监测和管理以及政策改革、改进诊断工具和提高公众意识倡议的重要性，以在全球范围内解决耐药性问题。
