一种来自猪肾的类分解代谢因子。
A catabolin-like factor from porcine kidney.
作者信息
Monserrat A J, Dingle J T
出版信息
Cell Biochem Funct. 1985 Jan;3(1):45-52. doi: 10.1002/cbf.290030110.
Explants of pig kidney cortex and medulla release a catabolin-like factor (CLF). The CLF of both kidney cortex and medulla can be precipitated with ammonium sulphate, mainly in the 60-95 per cent fraction. By gel chromatography the kidney CLF showed a major active fraction at a molecular weight of around 22 500. Whole glomeruli and dissociated glomerular cells in culture also released into the medium a CLF that could be bioassayed in live cartilage but displayed no effect on dead cartilage. The possible role of such a local hormone is discussed.
猪肾皮质和髓质的外植体释放出一种类分解代谢因子（CLF）。肾皮质和髓质的CLF都可用硫酸铵沉淀，主要在60%至95%的组分中。通过凝胶色谱法，肾CLF在分子量约为22500处显示出一个主要活性组分。培养中的完整肾小球和分离的肾小球细胞也向培养基中释放出一种CLF，这种CLF可在活软骨中进行生物测定，但对死软骨无作用。本文讨论了这种局部激素的可能作用。
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