抗类风湿药物对猪分解素生成及作用的影响。
Effects of antirheumatoid drugs on the production and action of porcine catabolin.
作者信息
Sheppeard H, Pilsworth L M, Hazleman B, Dingle J T
出版信息
Ann Rheum Dis. 1982 Oct;41(5):463-8. doi: 10.1136/ard.41.5.463.
Abstract
We report the effects of some common antirheumatic drugs on the production of catabolin from synovium and on its action on cartilage. A method is described to generate reproducible amounts of catabolin from synovial mince. Aspirin, Clozic (ICI 55,897), and gold were without effect on the catabolin system. Penicillamine at high doses enhanced the action of catabolin, while chloroquine inhibited catabolin's effect on cartilage. Prednisolone inhibited the production of catabolin without affecting its action. This inhibition was produced by very low doses of prednisolone (25 ng/ml) and was dose-dependent.
摘要
我们报告了一些常见抗风湿药物对滑膜中分解代谢素产生及其对软骨作用的影响。描述了一种从滑膜碎块中产生可重复量分解代谢素的方法。阿司匹林、氯唑昔（ICI 55,897）和金对分解代谢素系统无影响。高剂量青霉胺增强了分解代谢素的作用，而氯喹抑制了分解代谢素对软骨的作用。泼尼松龙抑制分解代谢素的产生但不影响其作用。这种抑制作用由极低剂量的泼尼松龙（25纳克/毫升）产生，且呈剂量依赖性。
相似文献
1
Effects of antirheumatoid drugs on the production and action of porcine catabolin.抗类风湿药物对猪分解素生成及作用的影响。
Ann Rheum Dis. 1982 Oct;41(5):463-8. doi: 10.1136/ard.41.5.463.
2
Characterization of catabolin, the major product of pig synovial tissue that induces resorption of cartilage proteoglycan in vitro.分解代谢素的特性研究，猪滑膜组织的主要产物，其可在体外诱导软骨蛋白聚糖的吸收。
Biochem J. 1981 Dec 1;199(3):705-14. doi: 10.1042/bj1990705.
3
A catabolin-like factor from porcine kidney.一种来自猪肾的类分解代谢因子。
Cell Biochem Funct. 1985 Jan;3(1):45-52. doi: 10.1002/cbf.290030110.
4
Partial purification of a factor from human synovium that possesses interleukin 1, chondrocyte stimulating and catabolin-like activities.从人滑膜中部分纯化出一种具有白细胞介素1、软骨细胞刺激活性和类分解素活性的因子。
FEBS Lett. 1985 Jan 7;179(2):247-51. doi: 10.1016/0014-5793(85)80528-7.
5
The effect of synovial catabolin on cartilage synthetic activity.滑膜分解素对软骨合成活性的影响。
Connect Tissue Res. 1984;12(3-4):277-86. doi: 10.3109/03008208409013690.
6
Characterization of proteins from human synovium and mononuclear leucocytes that induce resorption of cartilage proteoglycan in vitro.对来自人滑膜和单核白细胞的蛋白质进行表征，这些蛋白质在体外可诱导软骨蛋白聚糖的吸收。
Biochem J. 1983 Feb 1;209(2):337-44. doi: 10.1042/bj2090337.
7
Effects of anti-inflammatory drugs on cartilage recovery from catabolin-induced degradation.
Agents Actions. 1987 Jun;21(1-2):149-59. doi: 10.1007/BF01974935.
8
Experience with isoxicam and catabolin.异恶酰胺与卡他步林的使用经验。
Br J Clin Pharmacol. 1986;22 Suppl 2(Suppl 2):121S-124S. doi: 10.1111/j.1365-2125.1986.tb02992.x.
9
The cartilage-resorbing protein catabolin is made by synovial fibroblasts and its production is increased by phorbol myristate acetate.软骨吸收蛋白分解代谢素由滑膜成纤维细胞产生，其产量会因十四酰佛波醇乙酯而增加。
Biochem J. 1983 Nov 15;216(2):481-9. doi: 10.1042/bj2160481.
10
Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture.分解代谢素的鉴定，一种来自滑膜的可在器官培养中诱导软骨降解的蛋白质。
Biochem Biophys Res Commun. 1980 Oct 16;96(3):1225-31. doi: 10.1016/0006-291x(80)90082-0.
引用本文的文献
1
Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases.羟氯喹和氯喹在治疗系统性红斑狼疮、类风湿关节炎及相关疾病中的治疗和药理学特性。
Inflammopharmacology. 2015 Oct;23(5):231-69. doi: 10.1007/s10787-015-0239-y. Epub 2015 Aug 6.
2
The modulation of intra-articular inflammation, cartilage matrix and bone loss in mono-articular arthritis induced by heat-killed Mycobacterium tuberculosis.热灭活结核分枝杆菌诱导的单关节关节炎中关节内炎症、软骨基质和骨质流失的调节
Inflammopharmacology. 2005;12(5-6):551-67. doi: 10.1163/156856005774382607.
3
Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chondrocytes.实验性炎性关节炎中的关节软骨破坏：胰岛素样生长因子-1对软骨细胞蛋白聚糖代谢的调节
Histochem J. 1996 Dec;28(12):835-57. doi: 10.1007/BF02331388.
4
Isothiazolones interfere with normal matrix metalloproteinase activation and inhibit cartilage proteoglycan degradation.异噻唑啉酮会干扰正常的基质金属蛋白酶激活，并抑制软骨蛋白聚糖降解。
Biochem J. 1996 Sep 1;318 ( Pt 2)(Pt 2):417-24. doi: 10.1042/bj3180417.
5
Independent effects of interleukin 1 on proteoglycan synthesis and proteoglycan breakdown of bovine articular cartilage in vitro.
Agents Actions. 1993 May;39(1-2):82-90. doi: 10.1007/BF01975718.
6
Intracellular catabolin-like activity in cultured synovial tissue.培养的滑膜组织中的细胞内分解代谢素样活性。
In Vitro. 1983 Dec;19(12):892-6. doi: 10.1007/BF02661709.
7
Preliminary investigations on the pharmacological control of catabolin-induced cartilage destruction in vitro.关于体外药理控制分解代谢素诱导的软骨破坏的初步研究。
Agents Actions. 1985 Mar;16(1-2):55-7. doi: 10.1007/BF01999648.
8
Therapeutic effects on cartilage metabolism in arthritis as measured by release of proteoglycan structures into the synovial fluid.通过蛋白聚糖结构释放到滑液中所衡量的对关节炎软骨代谢的治疗效果。
Ann Rheum Dis. 1986 Jun;45(6):491-7. doi: 10.1136/ard.45.6.491.
9
Effects of antiinflammatory drugs on the release from porcine synovial tissue in vitro of interleukin 1 like cartilage degrading activity.抗炎药物对猪滑膜组织体外释放白细胞介素1样软骨降解活性的影响。
Agents Actions. 1987 Aug;21(3-4):337-40. doi: 10.1007/BF01966509.
10
Effect of antiinflammatory drugs on human interleukin-1-induced cartilage degradation.抗炎药物对人白细胞介素-1诱导的软骨降解的影响。
Agents Actions. 1987 Aug;21(3-4):334-6. doi: 10.1007/BF01966508.
本文引用的文献
1
Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture.分解代谢素的鉴定，一种来自滑膜的可在器官培养中诱导软骨降解的蛋白质。
Biochem Biophys Res Commun. 1980 Oct 16;96(3):1225-31. doi: 10.1016/0006-291x(80)90082-0.
2
Studies with 35S-labelled DL-penicillamine in patients with Wilson's disease.对威尔逊病患者进行的35S标记的DL-青霉胺研究。
Q J Med. 1971 Apr;40(158):275-87. doi: 10.1093/oxfordjournals.qjmed.a067270.
3
Tissue gold levels after chrysotherapy.金疗法后的组织金含量
Ann Rheum Dis. 1974 Nov;33(6):536-9. doi: 10.1136/ard.33.6.536.
4
[Pharmacokinetics and metabolism of D- and L-penicillamine. 1. Blood level, transport and protein binding].[D-青霉胺和L-青霉胺的药代动力学与代谢。1. 血药浓度、转运及蛋白结合]
Arzneimittelforschung. 1974 Jun;24(6):914-7.
5
6
Serum gold determinations in patients with rheumatoid arthritis receiving sodium aurothiomalate.接受硫代苹果酸金钠治疗的类风湿性关节炎患者的血清金含量测定。
Ann Rheum Dis. 1973 May;32(3):228-32. doi: 10.1136/ard.32.3.228.
7
The effect of synovial tissue on the breakdown of articular cartilage in organ culture.滑膜组织对器官培养中关节软骨降解的影响。
Arthritis Rheum. 1977 Sep-Oct;20(7):1359-71. doi: 10.1002/art.1780200710.
8
Glucocorticosteroid therapy: mechanisms of action and clinical considerations.糖皮质激素疗法：作用机制与临床考量
Ann Intern Med. 1976 Mar;84(3):304-15. doi: 10.7326/0003-4819-84-3-304.
9
Neutrophil chemotaxis in rheumatoid arthritis. Effect of D-penicillamine, gold salts, and levamisole.类风湿关节炎中的中性粒细胞趋化作用。青霉胺、金盐和左旋咪唑的影响。
Ann Rheum Dis. 1978 Feb;37(1):1-8. doi: 10.1136/ard.37.1.1.
10
A cartilage catabolic factor from synovium.一种来自滑膜的软骨分解代谢因子。
Biochem J. 1979 Oct 15;184(1):177-80. doi: 10.1042/bj1840177.
Zotero 插件