Maggi E, Mingari M C, Almerigogna F, Gerosa F, Moretta L, Romagnani S
Clin Immunol Immunopathol. 1985 Aug;36(2):168-75. doi: 10.1016/0090-1229(85)90118-7.
Human T cells active on B-cell proliferation are phenotypically and functionally heterogeneous. A series of 43 human T-cell clones, selected according to their ability to release factors active on B-cell proliferation, were analyzed. B-Cell proliferation was evaluated by two different assays, namely, a costimulation assay with anti-mu antibody or by an assay based on B-cell preactivation with Staphylococcus aureus. Eight of these clones expressed the T4-/T8+ phenotype while the remaining were T4+/T8-. The large majority had T-cell growth factor activity as well. However, some clones appeared to have B-cell growth factor activity only. Fourteen clones (eight T8+ and six T4+) also displayed cytolytic activity in a phytohemagglutinin-dependent cytolytic assay.
对B细胞增殖有活性的人T细胞在表型和功能上是异质性的。根据它们释放对B细胞增殖有活性的因子的能力，选择了一系列43个人T细胞克隆进行分析。通过两种不同的试验评估B细胞增殖，即抗μ抗体共刺激试验或基于用金黄色葡萄球菌预激活B细胞的试验。这些克隆中有8个表达T4-/T8+表型，其余的是T4+/T8-。绝大多数克隆也具有T细胞生长因子活性。然而，一些克隆似乎仅具有B细胞生长因子活性。在植物血凝素依赖性细胞溶解试验中，14个克隆（8个T8+和6个T4+）也表现出细胞溶解活性。
